Free NFL Pick: Titans vs. Cardinals Odds
Looking for Tennessee Titans vs. Arizona Cardinals Free NFL predictions? NFL betting sees the Titans taking on the Cardinals on 10/5 at State Farm Stadium, in Arizona. Cappers Picks provides complimentary expert handicapping picks on all NFL football matchups all season long so stay tuned for more FREE daily NFL predictions like this Titans Cardinals free pick.
2025 NFL Handicapping – Tennessee Titans vs Arizona Cardinals
(0-4) Tennessee Titans vs. Arizona Cardinals (2-2)
Date: Oct 05, 2025
Time: 4:05 PM ET
Venue: State Farm Stadium in Glendale, AZ
NFL Moneyline Odds: Titans +339 | Cardinals -444 (Bet Now!)
Today’s NFL Betting Odds: Titans +7.5 | Cardinals -7.5
NFL Football Gambling Total: O/U: 41.5
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Titans vs. Cardinals Gameday
In Week 5 of the 2025 NFL season, the Tennessee Titans travel to State Farm Stadium to face the Arizona Cardinals. The Titans, led by Head Coach Brian Callahan, are still searching for their first win, sitting at a rough 0-4 record. This is a team desperate to change the narrative.
Meanwhile, the Cardinals, under Head Coach Jonathan Gannon, sit at 2-2 and have shown both highs and lows. They split their home games, including a close loss to Seattle last week that highlighted both their competitiveness and inconsistency.
Arizona will look to use home field to bounce back.
Kickoff is scheduled for 4:05 PM on CBS. The Titans hope to finally snap their losing streak, while the Cardinals are focused on getting back on track in the NFC West.
With the retractable roof at State Farm Stadium, weather won’t be a factor.
Week 5, Tennessee Titans vs. Arizona Cardinals, has all the makings of a crucial midseason test.
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Tennessee Titans vs. Arizona Cardinals Odds & Last 5
Oddsmakers don’t have much faith in Tennessee. The Titans are big underdogs at +324, while the Cardinals are listed as heavy favorites at -417. The spread sits at 7.5 points in favor of Arizona, with bettors expecting the Titans to struggle on the road.
Tennessee’s most recent game was a disaster, a 26-0 shutout loss to the Houston Texans. Their offense managed only 93 passing yards and 10 first downs. Struggles moving the ball and finishing drives have been a constant theme this season.
Arizona, by contrast, has been competitive despite two losses. Their last outing was a narrow 23-20 defeat to Seattle.
The Cardinals already own wins over Carolina and New Orleans and appear far more capable of grinding out victories than their opponent this week.
Cardinals Stats
Arizona enters Week 5 with a balanced record and plenty of offensive upside. Quarterback Kyler Murray has thrown for 742 yards and six touchdowns. Even with a couple of picks, he remains the leader that gives Arizona a chance every week.
Marvin Harrison Jr. has wasted no time showing why he was drafted high, contributing 208 receiving yards and two touchdowns through four games. His chemistry with Murray is building quickly.
Running back Trey Benson is expected to take on a larger role due to injuries, which puts added pressure on the rookie.
Defensively, the Cardinals have been middle-of-the-pack. They rank 14th in opponent scoring and are seventh in fumble recoveries, but pass defense has been a problem, ranking 21st in yards allowed.
Veterans like Calais Campbell and Jalen Thompson provide stability, though consistency remains an issue.
Injuries are beginning to bite. James Conner and Sean Murphy-Bunting are both done for the season, which hurts depth on offense and in the secondary.
Arizona will need next men up to step in if they want to keep pace.
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Titans Stats
The Titans remain winless at 0-4 and look like a team in transition. Their 26-0 loss to Houston was ugly, and the offense has been lifeless. Through four games, they have failed to establish any rhythm, whether on the ground or through the air.
Quarterback Cameron Ward has thrown for 614 yards and just two touchdowns, ranking 33rd in the league. His efficiency has been limited, though he’s avoided catastrophic mistakes.
Running back Tony Pollard leads the ground game with 261 rushing yards and one score, giving Tennessee its only consistent production.
Defensively, the Titans haven’t been as poor as their record suggests. They rank ninth in combined interceptions and fumbles recovered. Still, they’ve given up too many yards — over 5,200 last season — and that problem has carried into 2025. Unless the defense can flip games with turnovers, it’s not enough.
Injuries pile on the misery. Wideout Treylon Burks and backup quarterback Will Levis are both out for the season.
Several others, including JC Latham and Bryce Oliver, remain banged up. Depth is thin, and that’s reflected in the product on the field.
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Titans vs. Cardinals QB Matchup
Kyler Murray remains the clear edge under center. He averages 214 passing yards per game with 1.6 touchdowns. His dual-threat skillset keeps defenses guessing and gives the Cardinals a dynamic offensive spark.
In contrast, Cameron Ward averages 184 yards per game and about one touchdown. His numbers are steady but unspectacular, and without help from his offensive line, he’s had little chance to stretch the field.
Tennessee Titans vs. Arizona Cardinals bottom line: Both quarterbacks carry pressure into this matchup, but Murray’s efficiency and playmaking make him the difference.
If Ward doesn’t elevate his game, the Titans could be staring at 0-5.
Tennessee Titans vs. Arizona Cardinals Football Betting Trends
- The Titans have gone 8-3 in their last 11 regular season games as underdogs for the over/under.
- The Titans are 1-3 against the spread in their last 4 regular season games as underdogs.
- Additionally, the Titans have lost 7 of their last 8 regular season games as underdogs straight up.
- The Cardinals have won all 3 of their last regular season games as favorites straight up.
- Also, the Cardinals have a 5-1 record in their last 6 regular season games as favorites for the over/under.
- The Cardinals are 2-1 against the spread in their last 3 regular season games as favorites.
Titans vs Cardinals Prediction: Over 41.5
The trends point squarely toward points in this matchup. The Titans have gone over in 8 of their last 11 games as underdogs, and while they’ve struggled to cover spreads, their games consistently tilt high-scoring.
Arizona fits that profile as well, clearing the total in 5 of their last 6 as favorites.
Four of their last five home games have also gone over, and with State Farm Stadium’s retractable roof eliminating weather concerns, both offenses should have every chance to click.
The Titans are clearly in a rough spot right now, and their defense hasn’t offered much resistance. That leaves the door wide open for the Cardinals, who, despite their own flaws, have enough firepower to take advantage.
Week 5 feels like a get-right spot for Arizona, and that usually means points on the board.
Given Tennessee’s history of playing in high-total games and Arizona’s ability to light up weaker defenses, the over 41.5 stands out. Expect a matchup where both teams contribute to pushing this number past the mark.
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NFL Betting Tweet Of The Day
Hungry for Sunday 🍽️ pic.twitter.com/jv0SmncWYU
— Arizona Cardinals (@AZCardinals) October 2, 2025
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