Free NFL Pick: Seahawks vs. Cardinals Odds
Looking for Seattle Seahawks vs. Arizona Cardinals Free NFL predictions? NFL betting sees the Seahawks taking on the Cardinals on 9/25 at State Farm Stadium, in Arizona. Cappers Picks provides complimentary expert handicapping picks on all NFL football matchups all season long so stay tuned for more FREE daily NFL predictions like this Seahawks Cardinals free pick.
2025 NFL Handicapping – Seattle Seahawks vs Arizona Cardinals
(2-1) Seattle Seahawks vs. Arizona Cardinals (2-1)
Date: Sep 25, 2025
Time: 8:15 PM ET
Venue: State Farm Stadium in Glendale, AZ
NFL Moneyline Odds: Seahawks -119 | Cardinals -101 (Bet Now!)
Today’s NFL Betting Odds: Seahawks -1.0 | Cardinals +1.0
NFL Football Gambling Total: O/U: 43
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Seahawks vs. Cardinals Gameday
As Week 4 of the 2025 NFL season kicks off, the Seattle Seahawks and Arizona Cardinals are set for a game at State Farm Stadium. Both teams hold a 2-1 record, indicating a balanced start to the season. The Seahawks, led by head coach Mike Macdonald, have shown strong performances on both home and road games.
On the other hand, the Arizona Cardinals, under head coach Jonathan Gannon, have also started the season with a 2-1 record. They aim to leverage their home-field advantage, having already secured a home victory this season.
This game will be huge for both teams as they look to gain momentum in the NFC West division.
Historically, the Seahawks have dominated recent encounters against the Cardinals, winning their last five meetings. However, games at State Farm Stadium have often been closely contested.
With both teams having strong starts to the season, this game is expected to be competitive.
Week 4, Seattle Seahawks vs. Arizona Cardinals, on Thursday Night Football, we’re all hoping a great game is in store.
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Seattle Seahawks vs. Arizona Cardinals Odds & Last 5
To begin, the odds slightly favor the Seahawks with a moneyline of -119, while the Cardinals stand at +100. The spread is set at -1.5 for Seattle and +1.5 for Arizona, indicating a close contest.
Both teams have shown offensive capabilities, but the total over/under of 43.5 suggests a balanced defensive effort might also be on display.
Looking at recent performances, Seattle’s offense has delivered strong results, especially in their last game against the Saints with a 44-13 victory. Their defense also held firm against the Steelers in Week 2. On the flip side, the Cardinals narrowly lost to the 49ers in Week 3, but their win over the Panthers in Week 2 demonstrated their ability to perform under pressure at home.
Furthermore, in head-to-head matchups, Seattle has had the upper hand recently, winning their last five encounters against Arizona. However, past games at State Farm Stadium have often been tight, as seen in their last visit where Seattle won 30-18.
With both teams aiming to improve their standings in the NFC West, the stakes are high for this matchup.
Cardinals Stats
To begin, the Arizona Cardinals are entering Week 4 with a 2-1 record. They recently faced a narrow defeat against the San Francisco 49ers, losing 16-15. Despite the loss, their defense held strong, limiting the 49ers to just 73 rushing yards.
In terms of offensive capabilities, Kyler Murray leads the Cardinals with 542 passing yards and four touchdowns this season. His connection with Trey McBride has been effective, with McBride accumulating 182 receiving yards.
The team will miss James Conner, who is out for the season due to a foot injury.
Defensively, the Cardinals rank 8th in sacks with 41 in the previous season, showcasing their ability to pressure quarterbacks. Dadrion Taylor-Demerson and Jalen Thompson have been key players in the secondary. Their defensive line will need to step up, considering injuries to key players like Justin Jones and L.J. Collier.
Finally, the Cardinals will play under the retractable roof of State Farm Stadium, which should provide a consistent environment. With a clear sky forecast, weather conditions won’t be a factor.
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Seahawks Stats
Seattle Seahawks are entering Week 4 with momentum after their recent performances. They secured a dominant win against the New Orleans Saints, scoring 44-13.
This victory followed another win over the Pittsburgh Steelers, showing their ability to perform both at home and on the road.
In terms of offensive stats, Sam Darnold has been a key player for the Seahawks. He has accumulated 663 passing yards over the first three games, placing him 14th in the league and first on the team. Kenneth Walker III has also contributed significantly with 163 rushing yards and three touchdowns, leading the team’s ground game.
Defensively, the Seahawks have shown strength, particularly in their pass rush. They recorded 45 sacks last season, ranking them sixth in the league. In their recent game against the Saints, Byron Murphy II stood out with a sack, adding to the team’s defensive prowess.
The Seahawks face challenges with several players on the injury report. Key players like Leonard Williams and Julian Love were limited in practice, which could impact their defensive lineup.
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Seahawks vs. Cardinals QB Matchup
Kyler Murray leads the Arizona Cardinals with an average of 180.7 passing yards and 35.7 rushing yards per game. He has thrown for 1.3 touchdowns on average, contributing to his fantasy points tally of 16.6 per game. Notably, he has avoided interceptions, showing precision with his downfield throws.
For the Seattle Seahawks, Sam Darnold has been effective, averaging 221 passing yards and 4.7 rushing yards per game. He has thrown 1.3 touchdowns per game, matching Murray in this aspect.
In terms of overall season performance, Murray has accumulated 542 passing yards over three games, ranking 25th in the league. He has also thrown four touchdowns, placing him 13th among quarterbacks. His ability to protect the ball is highlighted by only one interception, ranking him first in the league.
Darnold, on the other hand, has thrown for 663 yards over three games, placing him 14th in the league. He has matched Murray with four passing touchdowns, ranking 13th.
However, Darnold has thrown two interceptions, indicating room for improvement in ball security.
Seattle Seahawks vs. Arizona Cardinals Football Betting Trends
- The Seahawks are 7-0 straight-up in their last 7 away games.
- They are 5-0 against the spread in their last 5 away games.
- In games with totals of 42 or less, the Seahawks are 5-0 straight-up.
- Also, the Cardinals have a 3-0 straight-up record in their last 3 home games.
- In their last 4 home games, the Cardinals have seen the total go over each time.
- Additionally, the Cardinals are 5-2 against the spread in their last 7 home games.
Seahawks vs Cardinals Prediction: Over 43.5
The Cardinals have consistently been involved in shootouts at home, with the total going over in each of their last four games in Arizona. That recent trend points toward another high-scoring affair when they meet the Seahawks on Thursday night.
Additionally, Seattle has thrived in games with totals set at 42 or less, winning five straight in that situation. That kind of track record suggests they know how to dictate tempo in lower-numbered totals, often forcing opponents into higher-scoring games than expected.
This is a pivotal NFC West rivalry game on Thursday Night Football, and both teams bring plenty of motivation into it.
Historically, meetings between these two have delivered points as well. For example, in 2023 the Seahawks edged the Cardinals 20–10 in one matchup, but earlier that same season, they combined for 48 in Seattle, showing the volatility and scoring potential of this rivalry.
Arizona’s offense will miss James Conner, which could push them to lean more on their passing attack. On the other side, Seattle is beginning to find its stride offensively, especially with their balance in both the run and passing games.
All told, with the total set at 43.5 and both teams capable of capitalizing on defensive lapses, the over looks like the sharp play.
Expect fireworks under the primetime lights as this rivalry adds another chapter of high-scoring drama.
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NFL Betting Tweet Of The Day
🤩 Rivalries Giveaway 🤩
like + RT for a chance to win a signed @mcbtrey uni pic.twitter.com/rOLE3DDcSx
— Arizona Cardinals (@AZCardinals) September 23, 2025
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