Free NFL Pick: 49ers vs. Seahawks Odds
Looking for San Francisco 49ers vs. Seattle Seahawks Free NFL predictions? NFL betting sees the 49ers taking on the Seahawks on 9/7 at Lumen Field, in Seattle. Cappers Picks provides complimentary expert handicapping picks on all NFL football matchups all season long so stay tuned for more FREE daily NFL predictions like this 49ers Seahawks free pick.
2025 NFL Handicapping – San Francisco 49ers vs Seattle Seahawks
San Francisco 49ers vs. Seattle Seahawks
Date: Sep 07, 2025
Time: 4:05 PM ET
Venue: Lumen Field in Seattle, WA
NFL Moneyline Odds: 49ers -138 | Seahawks +116 (Bet Now!)
Today’s NFL Betting Odds: 49ers -2.5 | Seahawks +2.5
NFL Football Gambling Total: O/U: 43.5
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49ers vs. Seahawks Gameday
To kick off the 2025 NFL season, the San Francisco 49ers will travel to Seattle to take on the Seahawks at Lumen Field. With the game scheduled for Sunday, September 7, 2025, at 4:05 PM, fans can catch the action on FOX. The weather forecast suggests a mild day with scattered clouds and a light breeze, setting the stage for an exciting matchup.
The 49ers, led by head coach Kyle Shanahan, are coming off a preseason that included victories over the Los Angeles Chargers and Las Vegas Raiders. With strong performances from players like Jeff Wilson Jr. and Tanner Mordecai, they are looking to carry their momentum into the regular season. Additionally, their defense, coordinated by Robert Saleh, aims to make a significant impact against the Seahawks.
Meanwhile, the Seahawks, under the guidance of head coach Mike Macdonald, experienced a mixed preseason with a win against the Kansas City Chiefs and losses to the Green Bay Packers and Las Vegas Raiders. Drew Lock and Jalen Milroe have shown promise as quarterbacks, while the defense, led by Aden Durde, will need to step up to challenge the 49ers’ offense. As both teams belong to the NFC West, this game could set the tone for their divisional rivalry.
The recent history between these teams adds intrigue to the matchup, as the 49ers and Seahawks each won one of their encounters last season. The last time they met at Lumen Field, the 49ers emerged with a 36-24 victory. Week 1, San Francisco 49ers vs. Seattle Seahawks, we’re all hoping a great game is in store.
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San Francisco 49ers vs. Seattle Seahawks Odds & Last 5
Interestingly, the consensus odds place the 49ers as slight favorites with a moneyline of -138, while the Seahawks sit at +117. The spread reflects this close prediction, as the 49ers are favored by just 2.5 points. With a total of 43.5, bettors anticipate a moderately high-scoring game between these divisional rivals.
Reflecting on their preseason performances, the 49ers demonstrated consistency with two victories against the Chargers and Raiders. Conversely, the Seahawks had a more inconsistent preseason, highlighted by a solid win over the Chiefs but marred by losses to the Packers and Raiders. As such, both teams are looking to set the tone early in the regular season.
Historically, the head-to-head record from last season shows a split, with each team securing a win. Notably, the 49ers’ last visit to Lumen Field resulted in a 36-24 victory. Consequently, the Seahawks will be eager to defend their home turf and start the season on a positive note.
Seahawks Stats
To begin with, the Seattle Seahawks are set to kick off the 2025 season at Lumen Field against the San Francisco 49ers. Despite a mixed preseason, where they recorded one win, one tie, and one loss, the Seahawks are eager to start the regular season on a high note. The mild weather conditions with scattered clouds should provide a comfortable environment for this afternoon game.
Offensively, the Seahawks ended the 2024 regular season with a respectable 8th rank in passing yards, accumulating 4,020 yards. However, their rushing game lagged, ranking 27th with only 1,627 yards. This disparity highlights the importance of their passing game, led by players like Jaxon Smith-Njigba, who topped the team with 1,130 receiving yards last season.
On the defensive side, Seattle demonstrated strength with 45 sacks, ranking 6th in the league, and 13 interceptions, placing them 7th. This solid defensive performance helped them maintain an 11th rank in opponent scoring, allowing 368 points. Key defensive players like Jared Ivey and Alphonzo Tuputala will be crucial in stopping the 49ers’ offense.
In terms of recent form, the Seahawks’ preseason victory against the Kansas City Chiefs showcased their potential, as they dominated with 268 rushing yards and 209 passing yards. Drew Lock’s performance, with 129 passing yards and 2 touchdowns, was particularly noteworthy. However, the team will need to address the turnover issues that plagued them in their loss to the Green Bay Packers, where they fumbled five times.
Looking at the roster, Sam Darnold is projected to lead the Seahawks’ offense as the starting quarterback, with an expected 240.8 passing yards and 1.6 touchdowns in this game. Kenneth Walker III and Zach Charbonnet are anticipated to share the workload in the backfield, with Walker projected for 53.9 rushing yards. Their contributions will be vital in balancing the offensive attack.
Despite some injury concerns, including the absence of Kenny McIntosh for the season and several players listed as questionable, the Seahawks have the depth to field a competitive team. Players like Jaxon Smith-Njigba and Cooper Kupp are expected to lead the receiving corps, offering Darnold reliable targets. As the Seahawks prepare to host the 49ers, they will aim to leverage their home-field advantage and start the season with a win.
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49ers Stats
As the San Francisco 49ers prepare for their Week 1 matchup against the Seattle Seahawks, they enter the season with a solid offensive foundation. In the 2024 regular season, the 49ers ranked 4th in passing yards with 4,234, and their third-down conversion rate was an impressive 42.6%, placing them 9th in the league. This offensive prowess is led by quarterback Brock Purdy, who threw for 3,864 yards and 20 touchdowns last season.
However, the 49ers’ defense showed room for improvement, ranking 26th in opponent scoring with 436 points allowed last season. Despite this, their defense was effective in creating turnovers, ranking 9th in both opponent interceptions and fumbles recovered. The defense will be crucial in containing the Seahawks’ offensive threats at Lumen Field.
In recent preseason games, the 49ers demonstrated their potential by securing victories against the Los Angeles Chargers and Las Vegas Raiders. Notably, running back Jeff Wilson Jr. has been a consistent performer, contributing significantly in both games. Additionally, linebacker Nick Martin has been a standout on defense, showing his ability to disrupt opposing offenses.
As the 49ers look to build momentum into the regular season, they face several injury challenges. Key players like Demarcus Robinson and Brandon Aiyuk are out, while others such as Nick Bosa and Jauan Jennings are questionable for Week 1. These injuries could impact the 49ers’ depth and performance against a competitive Seahawks team.
On the offensive front, the 49ers will rely heavily on Christian McCaffrey, who is projected to rush for 80.8 yards and contribute 15.5 fantasy points in this game. Additionally, tight end George Kittle remains a vital target, projected to gain 66.6 receiving yards and 9.7 fantasy points. Their contributions will be critical in navigating the Seahawks’ defense.
Overall, the 49ers enter this matchup with a mix of optimism and caution. While their offensive capabilities are well-established, the defense will need to tighten up to counter the Seahawks’ offensive strategies. With key players sidelined, the 49ers’ depth will be tested as they aim to start the season on a positive note.
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49ers vs. Seahawks QB Matchup
Brock Purdy, the starting quarterback for the San Francisco 49ers, enters the 2025 season with high expectations. Last year, he played 15 games, accumulating 3,864 passing yards, which ranked 10th in the league, and threw 20 touchdowns. In this upcoming game against the Seattle Seahawks, Purdy is projected to pass for 257.7 yards and 1.6 touchdowns, making him a key player to watch.
On the other side, Sam Darnold leads the Seattle Seahawks as their starting quarterback. Although he did not play last season, he is set to make an impact in this opening week. Darnold is projected to throw for 240.8 yards and 1.6 touchdowns against the 49ers, which suggests a competitive performance in this matchup.
Both quarterbacks have the potential to shape the outcome of this game, given their projected stats. Purdy’s consistency from last season positions him as a reliable option for the 49ers, while Darnold’s fresh start with the Seahawks offers an opportunity to prove his capabilities. This dynamic sets the stage for an intriguing quarterback battle.
As the 49ers and Seahawks prepare to meet at Lumen Field, the performances of Purdy and Darnold will be crucial. The mild weather conditions with scattered clouds should provide an ideal setting for both quarterbacks to execute their game plans effectively. Fans can expect a competitive showdown between these two talented signal-callers.
San Francisco 49ers vs. Seattle Seahawks Football Betting Trends
- The 49ers have covered the spread in 2 out of their last 3 preseason games.
- The Seahawks have gone under the total in 2 of their recent preseason matchups.
- In their last 3 preseason games, the 49ers have a record of 2-1 straight-up.
- Also, the Seahawks have recorded a 1-1-1 straight-up record in their last 3 preseason games.
- Additionally, the 49ers have seen the total go over in 2 of their last 3 preseason contests.
- The Seahawks have failed to cover the spread in 2 of their recent preseason games.
49ers vs Seahawks Prediction: 49ers -2.5
The 49ers have built some positive momentum this preseason, winning two of their last three games straight up. That ability to grind out victories, even in tighter spots, points to a team ready to roll into the regular season.
In contrast, the Seahawks have been less convincing with a 1-1-1 preseason mark, showing flashes but not enough consistency. That lack of rhythm could prove costly against a well-rounded San Francisco roster.
Offensively, the Niners bring balance, ranking 4th in passing yards and 12th in rushing last season.
This dual-threat capability gives them multiple ways to stress Seattle’s defense and control the tempo.
Although Seattle’s defense finished 11th in points allowed last year, San Francisco’s 9th-ranked third-down conversion rate suggests they can sustain drives and wear down the unit. That efficiency often separates close games in divisional matchups.
With two ATS covers in their last three preseason contests, the 49ers have also shown they can deliver against betting expectations. Laying the small number at -2.5 looks like value, as San Francisco’s balance and sharper form tilt this NFC West battle their way.
49ers -2.5
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NFL Betting Tweet Of The Day
7️⃣2️⃣ through the years.
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— Seattle Seahawks (@Seahawks) September 5, 2025
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