– Last Updated on November 21, 2022 2:51 pm
Free NFL Prediction: 49ers vs Bills Odds
Looking for San Francisco 49ers vs. Buffalo Bills free picks? Week 6 NFL betting sees the 49ers taking on the Bills on Sunday October 16th at the Ralph Wilson Stadium in Orchard Park, New York. Cappers Picks provides complimentary handicapping picks all NFL season long so stay tuned for more FREE NFL predictions.
Week 6
(1-4) San Francisco 49ers vs. Buffalo Bills (3-2)
Date: Sunday October 16th
Time: 1:00 PM
Venue: Ralph Wilson Stadium, Orchard Park, New York
ATS Betting Lines: Buffalo Bills -7.5
NFL Moneyline Odds: Off
NFL Betting Total: 44
Live NFL Odds
Updated Sportsbook Bonuses For TodayClick here to view… NFL ATS Stats & Expert NFL Betting Insight!
The Bills are playing some really good ball right now. They have won three in a row and with this game against lightweight San Francisco they have a great opportunity to improve their position within the AFC.
It is amazing what a few wins can do to take the heat off a coach.
Check out the free sports picks from Cappers Picks experts today!
Kick off is set for 1:00 PM ET with the Bills carrying tons of momentum into this one.
They are playing better and winning, the perfect things to silence a weary fan base. Just beating New England might have been enough.
San Francisco 49ers
The 49ers put up a surprising performance on the very first Monday Night, blanking the Rams. Since then it has been four straight losses as Chip Kelly tries to get the program heading in the right direction.
At least in Philadelphia he was winning early.
With SF the running game has been OK but the passing game, featuring Blaine Gabbert is pathetic.
I don’t know if Colin Kaepernick can do any better but he has to be given a shot at this point.
Otherwise it is like they are not even trying.
Since that opening week shutout the defense has been pretty brutal…and things are getting worse with NaVorro Bowman heading to IR.
Check out the free College football picks from Cappers Picks experts today!
This team can’t afford to go at the tempo Kelly likes if the defense can’t stop people.
Up front they are hurting two with Glenn Dorsey and DeForest Buckner possibly missing this one. The Bills like to run the ball so the DL has to be better.
I was not expecting much from the 49ers this season…and we are getting it.
Buffalo Bills
The Bills seemed to have turned around their season and all it took was firing their offensive coordinator.
They are on a three game winning streak will want to carry as much momentum as possible into their game against New England at home in two weeks.
They are going to need it to stave off revenge.
Buffalo is not an elite offense but they are very good at running the ball. Speaking of revenge, Shady McCoy may be quite keen to have an impressive game against Chip Kelly, the man who traded him to Buffalo.
Check out the free NFL football picks from Cappers Picks experts today!
The run first offense should be able to have success as should the defense which has turned up their intensity after dropping the first two games of the season, Since then they have not given up more the 19 points in any game.
Lorenzo Alexander had three sacks last week and already has a career high 7 this season.
No reason he can’t continue looking like an All-Pro this week.
Jerry Hughes can also still bring it with 4 sacks through five games. When the defense is stout the offense can attack the way it wants to.
NFL Betting Trends:
- BUFFALO is 4-3 against the spread versus SAN FRANCISCO since 1992
- SAN FRANCISCO is 4-3 straight up against BUFFALO since 1992
- 4 of 7 games in this series have gone OVER THE TOTAL since 1992
- BUFFALO is 1-1 against the spread versus SAN FRANCISCO since 1992
- BUFFALO is 1-1 straight up against SAN FRANCISCO since 1992
- 1 of 2 games in this series have gone OVER THE TOTAL since 1992
4* Free NFL Betting Prediction: Buffalo -7.5
I am not ready to anoint Buffalo an AFC contender but I am warming on the idea. When they play well they can really make you feel it and for this one they do not have to be as sharp as normal.
NFL Free Score Prediction: Buffalo 28 – San Francisco 10
Look for the same play after play by Buffalo as the running game beats the 49ers into submission. I think we will see CK7 at some point.
If you’re looking for more picks like this San Francisco 49ers vs. Buffalo Bills matchup we’ll be providing 4* free NFL predictions on the blog all season long, and check out our Experts for guaranteed premium & free NFL Football picks!
CappersPicks.com has NFL odds up on a ton of futures, and you will also find 2016 NFL lines up for early games as well.