Free NFL Pick: Colts vs. Rams Odds
Looking for Indianapolis Colts vs. Los Angeles Rams Free NFL predictions? NFL betting sees the Colts taking on the Rams on 9/28 at SoFi Stadium, in Los Angeles. Cappers Picks provides complimentary expert handicapping picks on all NFL football matchups all season long so stay tuned for more FREE daily NFL predictions like this Colts Rams free pick.
2025 NFL Handicapping – Indianapolis Colts vs Los Angeles Rams
(3-0) Indianapolis Colts vs. Los Angeles Rams (2-1)
Date: Sep 28, 2025
Time: 4:05 PM ET
Venue: SoFi Stadium in Inglewood, CA
NFL Moneyline Odds: Colts +157 | Rams -187 (Bet Now!)
Today’s NFL Betting Odds: Colts +3.5 | Rams -3.5
NFL Football Gambling Total: O/U: 49.5
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Colts vs. Rams Gameday
The Indianapolis Colts head to SoFi Stadium with an undefeated record of 3-0. Under the guidance of head coach Shane Steichen, the Colts have shown strength both at home and on the road. Notably, their recent victory against the Tennessee Titans highlights their offensive capabilities.
Meanwhile, the Los Angeles Rams, led by head coach Sean McVay, stand at a 2-1 record. Despite a recent setback against the Philadelphia Eagles, the Rams have shown potential, especially in their home game against the Houston Texans.
Historically, the Rams have had success against the Colts, including a decisive win in 2017. However, each team has evolved since then, and the current season’s momentum could play a significant role.
Both teams are eager to claim victory in this pivotal Week 4 game.
In conclusion, the game between the Colts and Rams is set to be an exciting encounter. With both teams showcasing impressive performances so far, fans can expect an engaging contest.
Week 4, Indianapolis Colts vs. Los Angeles Rams, we’re all hoping a great game is in store.
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Indianapolis Colts vs. Los Angeles Rams Odds & Last 5
Diving into the game odds, the Colts enter as the underdogs with a moneyline of +155. Meanwhile, the Rams are favored at -185. Additionally, the point spread is set at +3.5 for the Colts and -3.5 for the Rams, indicating a competitive matchup.
Looking back at previous games, the Colts have maintained a perfect start, with a recent impressive 41-20 win against the Titans. Their offense showed significant strength with a balanced attack of 228 passing yards and 137 rushing yards. Moreover, Jonathan Taylor’s performance stood out with 102 rushing yards and 3 touchdowns.
On the other hand, the Rams faced a challenging game against the Eagles, falling short at 33-26.
Despite the setback, Matthew Stafford’s connection with Puka Nacua remained strong, as Nacua recorded 112 receiving yards.
Rams Stats
The Los Angeles Rams enter Week 4 with a mixed start to their 2025 season. They hold a record of 2-1, having recently fallen to the Philadelphia Eagles in a 33-26 away game. Despite the loss, the Rams displayed a strong running game, recording 160 rushing yards against the Eagles.
Additionally, the Rams’ offense is led by quarterback Matthew Stafford, who has accumulated 739 passing yards, ranking first in the league. Stafford has also thrown five touchdowns, placing him at the top in that category.
Wide receiver Puka Nacua has been a key target, leading the league with 333 receiving yards over three games.
On the defensive side, the Rams have shown strength in forcing turnovers, with 13 interceptions last season, ranking seventh. Their defense, however, has struggled to limit opponent offensive yards, ranking 26th last season.
The Rams will need to tighten up defensively to contain the Colts’ offensive threats.
Lastly, the Rams face some injury concerns with cornerback Ahkello Witherspoon and linebacker Keir Thomas both out. Guard Steve Avila and linebacker Nick Hampton are day-to-day, which could impact their depth.
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Colts Stats
The Indianapolis Colts are entering Week 4 with strong momentum. They have secured three consecutive wins, including a dominant 41-20 victory over the Tennessee Titans. Their offense has been effective, with quarterback Daniel Jones leading the charge with 816 passing yards, ranking him third in the league.
Furthermore, running back Jonathan Taylor has been instrumental in their success. He currently leads the league with 338 rushing yards and has scored three touchdowns. His performance has been complemented by wide receiver Michael Pittman Jr., who has 193 receiving yards and two touchdowns.
On the defensive side, the Colts have shown their ability to create turnovers.
They are ranked fourth in the league with 16 opponent passing interceptions. However, they will need to address their defense, which has allowed 6140 opponent offensive yards, placing them 29th in the league.
Lastly, the Colts are dealing with several injuries that could impact their performance. Notably, cornerback Kenny Moore II and wide receiver Alec Pierce are day-to-day with injuries.
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Colts vs. Rams QB Matchup
Matthew Stafford, the starting quarterback for the Los Angeles Rams, has been consistent in his performances this season. He has accumulated 739 passing yards over three games, ranking him ninth in the league. Additionally, Stafford has thrown five touchdowns and two interceptions, showing a balanced approach on the field.
In terms of projections for the upcoming game, Stafford is expected to pass for 254.5 yards and 1.6 touchdowns. His fantasy points projection stands at 15.3, indicating a solid performance against the Colts.
With a strong receiving corps, including Puka Nacua and Davante Adams, Stafford has the weapons to succeed.
On the other side, Daniel Jones leads the Indianapolis Colts with impressive stats this season. Over three games, he has thrown for 816 yards, placing him third in the league. Jones has also contributed three touchdowns without any interceptions.
For the upcoming game, Jones is projected to throw for 216.7 yards and 1.1 touchdowns. His fantasy points are estimated at 16.5, suggesting a competitive outing against the Rams.
With a reliable target like Michael Pittman Jr., Jones is poised to continue his strong start to the season.
Indianapolis Colts vs. Los Angeles Rams Football Betting Trends
- The Colts have gone 5-0 on the over in their last 5 away games.
- In games following a loss, the Colts are 5-0 on the over in their last 5 outings.
- Also, the Colts have a 4-0 record against the spread in their last 4 games.
- The Rams have a 6-0 straight-up record as favorites in their last 6 games.
- Additionally, the Rams are 6-0 against the spread as favorites in their last 6 games.
- In games after a win, the Rams have gone 3-0 on the over in their last 3 games.
Colts vs Rams Prediction: Rams -3.5 & Parlay with Rams ML -185
The Rams have quietly built momentum and now enter this matchup as the toughest test the Colts have faced so far. Notably, LA has been flawless in the favorite role, going 6-0 straight up in their last six such games, showing they can handle pressure when expected to win.
Indianapolis, on the other hand, has been a surprise at 3-0 but hasn’t faced an opponent with the Rams’ balance. Their defense remains unproven, and when it did face a capable offense in Denver, it allowed 28 points.
That raises questions about how it will handle Matthew Stafford as he continues to find rhythm after missing training camp.
At SoFi, the Rams should be able to control the game with time of possession while leaning on a defense that’s been opportunistic in creating takeaways. The Colts may continue their trend of overs on the road, but keeping pace here feels like a tall order.
With Stafford heating up and the Rams thriving at home, this looks like another spot where LA asserts itself as a reliable favorite.
Given the Rams’ consistency in this role and Indy’s untested defense, betting the Rams -3.5 and parlaying the juice on the moneyline at -185 are the right sides.
Expect Los Angeles to extend its streak as favorites and hand the Colts their first loss of the season.
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