Free Week 16 Prediction: Colts vs. Cardinals NFL Odds
Looking for Indianapolis Colts vs. Arizona Cardinals free NFL Week 16 picks & NFL odds? NFL betting sees the Colts taking on the Cardinals on Saturday, December 25th at State Farm Stadium in Glendale, Arizona. Cappers Picks provides complimentary handicapping picks all NFL season long including all NFL Week 16 games so stay tuned for more FREE NFL predictions like this Indianapolis Arizona matchup.
NFL Handicapping Analysis: Week 16
(8-6) Indianapolis Colts vs. Arizona Cardinals (10-4)
Date: Saturday, December 25th, 2021
Time: 8:15 PM ET
Venue: State Farm Stadium, Glendale, Arizona
NFL Week 16 ATS Betting Lines: Cardinals PK(Bet Now!)
NFL Week 16 Moneyline Odds: Colts OFF| Cardinals OFF
NFL Week 16 NFL Betting Total: 49.5
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The Arizona Cardinals had one of the biggest letdowns of the entire season last week in a 30-12 loss at Detroit. There’s really no time to sulk though as one of the hottest teams in the AFC comes to town when the Colts visit in this week 16 matchup.
Indianapolis is fresh off a 27-17 win over the Patriots, who were the AFC’s #1 seed at the time. The Colts are playing good defense, running the football as well as anybody in the league, and building confidence week by week which is why oddsmakers have this game a pick ’em.
Indianapolis Colts
Indy has definitely worked out the kinks following their 0-3 start, going 8-3 since then with each of those losses coming by one score – two of them in overtime.
The biggest factor in the Colts turnaround is budding superstar Jonathan Taylor, who has ran for 100+ yards in five of the last six games. That includes going for 170 yards last week against a good Patriots defense, and now Taylor faces Arizona’s #18 rank unit vs. the run (112.8 ypg).
Despite how well the Colts are playing, it’s still going to be a tough challenge going to the desert and getting a win. Indianapolis will almost assuredly need a better performance from QB Carson Wentz, who was just 5/12 for 57 yards vs. New England.
The Colts defense has to come into this game with a little more confidence after Arizona was held to 12 points last week by Detroit’s #29 ranked defense in total yards allowed (380.5). Detroit lost 38-10 in Detroit the week prior.
Arizona Cardinals
Arizona just has to call last week’s loss to Detroit a wash and move on. The Cardinals are still in a good spot at 10-4 and in a tie with the Rams for the NFC West lead. The head to head loss to 11-3 Green Bay does hurt Arizona’s chances at a possible #1 seed though.
It’s really hard to explain just how the Cardinals lost to the Lions last week, even on the road. Craig Reynolds did run the ball 28 times for 112 yards for the Lions, and Jared Goff was very efficient going 21/26 with 3 TDs.
The fact that the Lions were able to move the ball through the air is a bit concerning for an Arizona defense that ranks 5th in the NFL allowing just 210 yards/game. Wentz didn’t do much last week, but does have 23 TDs to 6 INT on the season.
The Cardinals have now allowed 30+ points in back to back games, suffering a 30-23 home loss to the Rams in week 14. Arizona is just 3-3 at home on the season, and face a really good road team in the Colts who are 4-2 away from Lucas Oil Stadium.
NFL Betting Trends:
- Colts are 5-0 ATS last 5 road games
- Colts are 4-1 ATS last 5 Saturday games
- Colts are 8-3 ATS last 11 overall
- OVER is 4-1 in Colts last 5 road games
- Cardinals are 3-8 ATS last 11 home games
- Cardinals are 1-4 ATS last 5 Saturday games
4* Free Week 16 NFL Betting Prediction: Colts PK
This game could really go either way, but there’s some legitimate concerns for the Arizona defense right now after giving up 60 points the last two weeks. Indy can run the ball, and have an experienced QB in Wentz who minimizes mistakes.
Home field advantage doesn’t mean much for Arizona this season.
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