Free NFL Pick: Cardinals vs. Seahawks Odds
Looking for Arizona Cardinals vs. Seattle Seahawks Free NFL predictions? NFL betting sees the Cardinals taking on the Seahawks on 11/9 at Lumen Field, in Seattle. Cappers Picks provides complimentary expert handicapping picks on all NFL football matchups all season long so stay tuned for more FREE daily NFL predictions like this Cardinals Seahawks free pick.
2025 NFL Handicapping – Arizona Cardinals vs Seattle Seahawks
(3-5) Arizona Cardinals vs. Seattle Seahawks (6-2)
Date: Nov 09, 2025
Time: 4:05 PM ET
Venue: Lumen Field in Seattle, WA
NFL Moneyline Odds: Cardinals +253 | Seahawks -312 (Bet Now!)
Today’s NFL Betting Odds: Cardinals +6.5 | Seahawks -6.5
NFL Football Gambling Total: O/U: 45.5
Here’s why I’m backing a Seattle ATS bet below in my Cardinals Seahawks free pick & gambling prediction for this matchup.
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Cardinals vs. Seahawks Gameday
There isn’t a better uniform combo in the NFL than the Hawks retro uniform picture above — and there isn’t a hotter team right now than the Seattle either. They enter as -6.5 favorites for a reason, and it’s hard to argue against them covering that number.
As Week 10 of the 2025 NFL season unfolds, the Arizona Cardinals travel north to take on the Seahawks at Lumen Field. The game kicks off Sunday at 4:05 PM on CBS, with overcast skies and cool Pacific Northwest weather setting the stage for a gritty divisional battle.
The Cardinals, sitting at 3-5, come off an impressive 27-17 win over the Dallas Cowboys.
Head coach Jonathan Gannon’s squad has been competitive, especially on the road, where they’ve gone 2-2.
However, they were dealt a major setback this week as quarterback Kyler Murray was officially placed on injured reserve Wednesday night, leaving veteran Jacoby Brissett to carry the load.
Meanwhile, Seattle is flying high at 6-2 under first-year head coach Mike Macdonald. The Seahawks are playing as well as any team in the league, boasting a dominant defense and a big-play offense that’s been shredding opponents.
They’ve shown balance, poise, and explosiveness — the hallmarks of a legitimate contender.
Week 10, Arizona Cardinals vs. Seattle Seahawks — buckle up, because this one should deliver.
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Arizona Cardinals vs. Seattle Seahawks Odds & Last 5
The Seahawks enter as firm favorites with a moneyline of -312, while the Cardinals sit at +251. The spread is set at Seattle -6.5, and the total is pegged at 45.5 — suggesting oddsmakers expect Seattle’s offense to do most of the heavy lifting.
Arizona has been feisty lately, picking up a win over Dallas after a tough stretch of losses. They’ve proven capable of scoring on the road, but losing Murray changes everything. Brissett will be tasked with managing the game efficiently and avoiding turnovers against one of the NFL’s stingiest defenses.
Seattle, on the other hand, has been on a heater. Their 38-14 demolition of Washington was their fourth straight win, and they’ve now outscored opponents 134-61 over that span.
The Seahawks have been nearly unbeatable on the road, but at home it’s a little dicey. Having said that, with the Cardinals playing consecutive road games on a short week, the situational edge here leans heavily toward Seattle.
Seahawks Stats
The Seahawks are rolling into Week 10 with all the momentum in the world. Quarterback Sam Darnold has revitalized his career, throwing for 330 yards and four touchdowns in last week’s win over the Commanders.
Seattle’s offense ranks 8th in passing yards from last season and has continued that upward trend, with Darnold spreading the ball efficiently to multiple targets.
Defensively, Seattle has been flat-out nasty. They rank 11th in opponent scoring and 6th in sacks, with their front seven consistently wrecking opposing offensive lines. That defensive dominance, paired with timely turnovers, has been the key to their surge.
Injuries are always a factor, but Seattle has stayed relatively healthy. Cooper Kupp and Jake Bobo are listed as questionable, though both are expected to suit up. The Seahawks acquired Rashid Shaheed from the Saints on Tuesday in exchange for 2026 4th/5th picks, he’ll help out the WR room here, and knows Kubiak’s offense.
The Seahawks’ depth and versatility have been on full display, and they look every bit like a team ready to make a deep playoff push. Did I mention DVOA?
OK, now the controversial one.
After last night’s dominant victory, Seahawks now 4th in DVOA through 8 games since 1978. Yes, this table also has Colts from last week. They’re now third, behind the Rams.
Will be writing tomorrow about Seahawks gap between DVOA and EPA. pic.twitter.com/qAKcBRLnhd
— Aaron Schatz 🏈 (@ASchatzNFL) November 3, 2025
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Cardinals Stats
Arizona enters Week 10 trying to keep momentum alive after their win over Dallas. Jacoby Brissett was sharp in that game, throwing for 261 yards and two touchdowns.
But now, without Kyler Murray, the Cardinals’ offensive ceiling takes a significant hit. Murray’s mobility and ability to extend plays will be sorely missed as he spends time on injured reserve.
The Cardinals’ strength lies in their ground game. They ranked 7th in rushing last season and continue to lean on Emari Demercado, who rushed for 79 yards in last week’s win. Expect a heavy dose of the run game again, as Arizona looks to keep Darnold and the Seahawks’ offense off the field.
Defensively, the Cardinals rank 8th in sacks with 41 and continue to generate pressure up front. Calais Campbell has been ageless, adding two sacks last week.
However, this unit struggles against the pass, allowing over 5,800 yards last season — a weakness that Darnold and Seattle’s playmakers are primed to exploit. (Did you watch them on Sunday night?)
Cardinals vs. Seahawks QB Matchup
Sam Darnold is finally putting it all together in Seattle. With 2,084 passing yards through eight games, he ranks 7th in the league, alongside 16 touchdowns and just five interceptions.
His poise in the pocket and growing chemistry with his receivers have turned Seattle’s offense into a weekly highlight reel.
Arizona’s quarterback situation, on the other hand, is suddenly in flux. Jacoby Brissett remains steady but limited — 860 passing yards, six touchdowns, and only one interception across five games. He’ll need to rely on short throws and the run game to keep the offense afloat.
With Murray sidelined, the Cardinals lose their “best playmaker” and most dynamic weapon.
Simply put, Darnold is in rhythm, and Brissett is in survival mode. That contrast could define the afternoon at Lumen Field.
Arizona Cardinals vs. Seattle Seahawks bottom line: Seattle’s defense is smothering, their offense is rolling, and Arizona’s down its star quarterback. The Seahawks should control this one from the start and comfortably cover at home.
Arizona Cardinals vs. Seattle Seahawks Football Betting Trends
- The Cardinals are 4-0 ATS in their last 4 away games.
- They are 3-0 ATS in their last 3 games as underdogs.
- Additionally, the Cardinals have gone over the total in 2 of their last 3 games as underdogs.
- The Seahawks are 7-1 SU in their last 8 games as favorites.
- Also, the Seahawks are 7-1 ATS in their last 8 games as favorites.
- The Seahawks have gone over the total in their last 3 home games.
Cardinals Seahawks Free Pick: Seahawks -6.5
Here is my Seahawks Cardinals free pick. I’m locking in the Seattle Seahawks ATS -6.5 because their dominance as favorites and proven track record against Arizona make them the clear side to back.
Seattle has gone 7-1 straight up and 7-1 ATS in its last eight games as favorites and 6-1 ATS overall in its last seven. They’ve also won five of their last six against NFC West opponents and gone over the total in their last three home games at Lumen Field, showing their balanced form on both sides of the ball.
Seattle has completely owned this rivalry, with Arizona going 1-7 ATS and 0-8 straight up in their last eight meetings, and that trend doesn’t look ready to change.
The Cardinals sit at 3-5 this season and have dropped 13 of their last 16 against NFC West foes, struggling to stay competitive away from home. With the Seahawks’ defense ranking 11th in opponent scoring and 6th in sacks last year, they have the personnel to handle Arizona’s offense efficiently.
Given Seattle’s consistency, divisional dominance, and home-field edge, the Seahawks -6.5 remain the sharp play. Parlaying with the moneyline adds value—my system is locking in Seattle on every front this Sunday.
I hate the word “lock”, but this door is closed.
Today’s NFL Free Pick
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NFL Betting Tweet Of The Day
Different kind of play speed. 😤 @RashidShaheed pic.twitter.com/rPJTHKCwFa
— Seattle Seahawks (@Seahawks) November 6, 2025
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