Free NFL Pick: Cardinals vs. Saints Odds
Looking for Arizona Cardinals vs. New Orleans Saints Free NFL predictions? NFL betting sees the Cardinals taking on the Saints on 9/7 at Caesars Superdome, in New Orleans. Cappers Picks provides complimentary expert handicapping picks on all NFL football matchups all season long so stay tuned for more FREE daily NFL predictions like this Cardinals Saints free pick.
2025 NFL Handicapping – Arizona Cardinals vs New Orleans Saints
Arizona Cardinals vs. New Orleans Saints
Date: Sep 07, 2025
Time: 1:00 PM ET
Venue: Caesars Superdome in New Orleans, LA
NFL Moneyline Odds: Cardinals -286 | Saints +234 (Bet Now!)
Today’s NFL Betting Odds: Cardinals -6.5 | Saints +6.5
NFL Football Gambling Total: O/U: 43.5
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Cardinals vs. Saints Gameday
As the 2025 NFL season kicks off, the Arizona Cardinals travel to the Caesars Superdome to play the New Orleans Saints. This Week 1 matchup is set for September 7th, with the game starting at 1:00 PM. Fans can catch the action on CBS as these two teams begin their new campaigns.
Under the leadership of head coach Jonathan Gannon, the Cardinals aim to build on their recent preseason performances. Their offensive coordinator Drew Petzing and defensive coordinator Nick Rallis will be crucial in navigating the NFC West challenges. Recently, the Cardinals showcased a strong ground game in their preseason finale against the Raiders, rushing for 210 yards.
The Saints, led by head coach Kellen Moore, are eager to start the season on a positive note at home. Despite some setbacks in the preseason, their passing game, led by offensive coordinator Doug Nussmeier, showed potential, tallying 248 passing yards against the Jaguars. Defensive coordinator Brandon Staley will look to tighten the defense, especially after allowing 293 passing yards to the Broncos.
Historically, these teams have had competitive encounters. Their last preseason meeting saw the Saints narrowly winning 16-14 against the Cardinals. With both teams eager to start strong, this game promises to be a captivating start to the season.
Week 1, Arizona Cardinals vs. New Orleans Saints, we’re all hoping a great game is in store.
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Arizona Cardinals vs. New Orleans Saints Odds & Last 5
Interestingly, the odds for this matchup favor the Cardinals with a moneyline of -283, while the Saints are at +232. The spread has the Cardinals at -6.5 with odds of -108, and the Saints receiving +6.5 at -111. The over/under is set at 43.5, indicating expectations of a moderately scoring game.
In terms of historical performance, the Cardinals and Saints have faced each other multiple times over the years. Their most recent preseason encounter resulted in a close victory for the Saints, who edged out the Cardinals 16-14. In regular season play, the 2022 game saw the Cardinals emerge with a 42-34 win, showcasing their offensive capabilities.
Both teams have had mixed results in recent preseason outings, with the Cardinals finishing on a high note by defeating the Raiders 20-10. Meanwhile, the Saints struggled against the Broncos in their final preseason game, losing 28-19. Despite these preseason outcomes, both teams will aim to start the regular season with strong performances.
Saints Stats
To kick off the 2025 season, the New Orleans Saints will host the Arizona Cardinals at the Caesars Superdome. The Saints are looking to improve from their previous regular season, where they ranked 23rd in both scoring and passing yards. However, their rushing game showed promise, finishing 14th in the league with 1,954 yards.
In the 2024 season, the Saints’ defense was a mixed bag, ranking 18th in opponent scoring but 30th in opponent offensive yards allowed. They were strong in creating turnovers, ranking 6th in opponent passing interceptions with 14. Additionally, they managed to secure 39 sacks, placing them 10th in the league.
Preseason results have been less than ideal for the Saints, as they ended with losses in all three games. Their most recent game against the Denver Broncos ended in a 28-19 defeat, with the Saints struggling to match Denver’s 293 passing yards. Despite these setbacks, the team will aim to leverage their home-field advantage to start the regular season on a positive note.
Quarterback Spencer Rattler will be a focal point for the Saints, projected to lead with 219.9 passing yards and 1.3 touchdowns in the upcoming game. Rattler’s performance will be crucial, especially given Derek Carr’s absence due to injury. The offensive line will need to protect Rattler effectively to capitalize on his potential.
Alvin Kamara remains a key player in the Saints’ offensive strategy, projected to contribute 60.4 rushing yards and 4 receptions. Kamara’s dual-threat capability as a runner and receiver will be vital, especially with the Saints’ need to diversify their offensive plays. His performance will be instrumental in keeping the Cardinals’ defense on their toes.
On the injury front, the Saints face challenges with several key players out, including Taysom Hill and Foster Moreau. The absence of these players, along with others on the injured reserve, will test the depth of the Saints’ roster. Nevertheless, the team will look to their leaders and emerging talents to fill the gaps and secure a win in their season opener.
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Cardinals Stats
To begin, the Arizona Cardinals enter the 2025 NFL season with a mix of optimism and challenges. Last season, they ranked 12th in scoring with 400 points and demonstrated a strong rushing attack, finishing 7th with 2,451 rushing yards. However, their passing game lagged slightly, ranking 18th with 3,639 yards.
Furthermore, the Cardinals’ defense showed notable strengths and some areas for improvement. They excelled in generating pressure, securing 41 sacks to rank 8th in the league. However, they allowed 5,823 opponent offensive yards, placing them 21st, indicating room for improvement in limiting opposing offenses.
During the preseason, the Cardinals displayed mixed results, winning two out of three games. They secured victories against the Kansas City Chiefs and Las Vegas Raiders, while suffering a loss to the Denver Broncos. Notably, their rushing game was a highlight, with Bam Knight contributing significantly in the matchup against the Raiders.
Looking at individual performances, Kyler Murray remains a key figure for the Cardinals. In the 2024 season, he passed for 3,851 yards, ranking 11th in the league, and contributed 21 touchdowns. Murray’s ability to impact games with both his arm and legs will be vital for Arizona’s offensive success.
On the injury front, the Cardinals face significant setbacks with several key players sidelined. Notable absences include Sean Murphy-Bunting, who will miss the entire season, and BJ Ojulari, who is out for at least four games. These injuries will test the depth and resilience of Arizona’s roster early in the season.
Finally, the Cardinals’ offense will rely heavily on their top playmakers, including Marvin Harrison Jr. and Trey McBride. Harrison Jr. is projected to lead the receiving corps with 58.5 yards per game, while McBride is expected to be a key target with 66.2 receiving yards per game. Their contributions will be crucial as the Cardinals aim to start the season on a positive note against the New Orleans Saints.
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Cardinals vs. Saints QB Matchup
Kyler Murray, the starting quarterback for the Arizona Cardinals, enters the 2025 season after a solid 2024 campaign. Last year, he played 17 games, throwing for 3,851 yards, which ranked 11th in the league. Additionally, he threw 21 touchdown passes, placing him 13th in that category, while also recording 11 interceptions. For this matchup against the New Orleans Saints, Murray is projected to throw for 223.1 yards and 1.5 touchdowns, with no interceptions expected.
Spencer Rattler, leading the New Orleans Saints, is looking to make an impact in his first full season as the starting quarterback. In the 2024 season, Rattler played in seven games, amassing 1,317 passing yards and four touchdowns. Despite his limited action, he showed promise, and for this game, he is projected to pass for 219.9 yards and 1.3 touchdowns, while also avoiding interceptions.
Both quarterbacks have the potential to influence the outcome of this game significantly. Murray’s experience and ability to make plays with his legs add another dimension to the Cardinals’ offense. Meanwhile, Rattler’s youthful energy and potential for growth could provide the Saints with a dynamic offensive presence as they kick off their season at home.
As the Cardinals and Saints prepare to meet at the Caesars Superdome, the performance of these two quarterbacks will be crucial. With Murray’s established track record and Rattler’s potential for development, this game sets the stage for an intriguing quarterback battle. Fans can expect a competitive matchup as both teams aim to start their 2025 season on a positive note.
Arizona Cardinals vs. New Orleans Saints Football Betting Trends
- The Cardinals have a recent preseason record of 2-1, winning against the Raiders and Chiefs, but losing to the Broncos.
- Also, the Saints have struggled in their preseason games, recording a 0-2-1 record with losses to the Broncos and Chargers, and a tie with the Jaguars.
- In terms of point totals, the Cardinals’ games have seen scores of 30, 34, and 37, indicating a mix of low to moderate scoring affairs.
- The Saints’ games have had point totals of 40, 34, and 40, suggesting a trend towards moderate scoring contests.
- Additionally, the Cardinals have shown strong rushing performances, particularly in their game against the Raiders, where they amassed 210 rushing yards.
- The Saints have displayed a tendency for turnovers, with interceptions in each of their preseason matchups, including two against the Chargers.
Cardinals vs Saints Prediction: Cardinals -6.5
The Cardinals enter this matchup with confidence after preseason wins over the Raiders and Chiefs. Their ability to establish the run, especially against Las Vegas, showcased an offense that looks ready to carry momentum into the regular season.
Meanwhile, the Saints failed to notch a preseason victory, and their struggles with turnovers—particularly interceptions—remain a glaring concern. Against a defense like Arizona’s that thrives on takeaways, those mistakes could easily swing the game.
Looking back at last season, the Cardinals held statistical advantages in both scoring offense and rushing production.
That balance, paired with a defense that ranked high in sacks and fumble recoveries, makes them well-suited to exploit New Orleans’ weaknesses.
While the Saints will enjoy home-field advantage inside the Caesars Superdome, their lack of preseason sharpness raises questions about whether they can truly capitalize. The Cardinals, by contrast, appear more disciplined and efficient on both sides of the ball.
Considering Arizona’s preseason form, their statistical edge, and New Orleans’ turnover woes, the Cardinals look like the stronger play. Laying the small price on the moneyline at -125 provides value in a matchup that tilts in their favor.
Hammer Cardinals ATS.
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NFL Betting Tweet Of The Day
Top 50 Home Games in Saints history & looking back at a MNF classic: Drew Brees throws for a perfect 158.3 Passer Rating in route to a 38-17 victory over the Patriots to improve to 11-0 ⚜️
See Games 30-21 on https://t.co/KlYFEtTVGF#Saints | @CaesarsSports pic.twitter.com/xvCN61f329
— New Orleans Saints (@Saints) September 4, 2025
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