San Diego Padres vs. Toronto Blue Jays 5/21/2025 Free Pick & MLB Betting Prediction

Free MLB Pick: Padres vs. Blue Jays Odds

Looking for San Diego Padres vs. Toronto Blue Jays Free MLB predictions? MLB betting sees the Padres taking on the Blue Jays on Wednesday, May 21st, 2024 at Rogers Centre, in Toronto, ON. Cappers Picks provides complimentary expert handicapping picks on all MLB baseball matchups all season long so stay tuned for more FREE daily MLB predictions like this Padres Blue Jays free pick.

2025 MLB Handicapping – San Diego Padres vs Toronto Blue Jays

(27-19) San Diego Padres vs. Toronto Blue Jays (23-24)
Date: Wednesday, May 21st
Time: 7:07 ET
Venue: Rogers Centre Toronto, ON
Projected Starting Pitchers: Randy Vásquez vs. Kevin Gausman
MLB Moneyline Odds: Padres +130 | Blue Jays -153 (Bet Now!)
Today’s MLB Run Line Betting Odds: Padres +1.5 | Blue Jays -1.5
MLB Baseball Gambling Total: O/U: 8.5

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Padres vs. Blue Jays Gameday

Wednesday’s interleague matchup between the Padres and Blue Jays has a start time of 7:07 PM ET from the Rogers Centre in Toronto. The Blue Jays are favored on the money line, with their odds sitting at -153 compared to the Padres at +130. The over/under line is currently at 8.5 runs.

Padres are starting Randy Vasquez, while the Blue Jays have Kevin Gausman on the mound. The Padres are 27-19 this season, while the Blue Jays are 23-24. Toronto is currently in 3rd place in the AL East, while the Padres are 3rd in the NL West. SDPA is 4-6 over their last 10, while the Blue Jays have won 4 of their last 5.

Toronto picked up a 3-0 win over the Padres in the most recent game of this series. The Blue Jays had a huge 5th inning, scoring all three of their runs. As for the Padres, they had their best scoring chance in the 7th, but could only muster two hits. Heading into the game, the Blue Jays were the slight favorites at -105.

Chris Bassitt got the win for the Blue Jays, going six innings and not giving up a run. He finished the game with six strikeouts but issued a season-high seven walks. Jeff Hoffman got the save. Dylan Cease had a rough outing for the Padres, taking the loss.

Vladimir Guerrero Jr. and Anthony Santander each homered for the Blue Jays. Guerrero Jr. went 1/3 with two RBIs and a run scored. Santander also had a two RBI game at the plate.

San Diego is on the road today, looking to pick up a win vs. the Blue Jays and snap their four-game losing streak. The Padres are 27-19 overall, putting them 3rd in the NL West. They are 1.5 games behind the Dodgers for the division lead. So far, they have been great vs. other teams in the NL West, going 7-1.

At home, the Padres are 16-8 this year compared to 11-11 on the road. As the underdog, the Padres have an overall record of 27-19 this year, and they have dropped four straight as the underdog. San Diego’s overall series record is 9-6 heading into today’s game two vs. the Blue Jays. Over the last 10 games, the Padres are 4-6.

Padres Stats

San Diego comes into today’s game with the league’s best strikeout rate, and they are also one of the top home run hitting teams in the league. Overall, they are averaging 4.3 runs per game, which is 14th in the MLB. The Padres have been a good home run hitting team and have the league’s 6th best team batting average at .259.

Fernando Tatis Jr. has been the Padres’ top power threat this season, as his 12 homers is 6th best in the league. However, he has hit just .217 over his last six games. Overall, he is batting .303 for the season. Luis Arraez comes into the game on a seven-game hitting streak and has gone 8/23 in his last six games.

Toronto is 3rd in the AL East, trailing the Yankees by five games. Overall, the Blue Jays are 23-24 as they get set to host the Padres today. Toronto took the series opener, and their overall series record is 5-8-2 this year.

At home, the Blue Jays are 14-12 this year, and they are just under .500 at 9-12 on the road. So far, they have yet to win a game as the favorite. As for their record as the underdog, it is also 23-24. Looking at their overall record, the Blue Jays are 10-9 in AL East matchups.

Blue Jays Stats

As a team, the Blue Jays are averaging 3.9 runs per game, which is 23rd in the league. They have been slightly better at home, putting up 4.1 runs per contest. So far, they are 15th in home runs and have the 11th best team batting average in the league. Overall, their team on-base percentage, slugging percentage, and OPS are all right around the league average.

Bo Bichette has been swinging a hot bat of late, going 9/32 over his last eight games with two homers. For the season, he is batting .286 and is the team’s top run producer. Vladimir Guerrero Jr. and Anthony Santander are also tied for the team lead in homers, but Santander has really struggled this season, hitting just .185.

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Padres Blue Jays Pitching

Randy Vásquez is getting the start for the Padres today as he faces the Blue Jays on the road. So far this season, he has made nine starts and three of them have been quality starts. Vásquez’s ERA for the season is 3.45, along with a record of 3-3. In his last outing, he gave up just one earned run in six innings of work, picking up the win. Before that, he had given up at least two earned runs in three straight starts. Vásquez’s ERA on the road is 7.49 compared to 2.27 at home.

Blue Jays starter Kevin Gausman will be looking to bounce back from a rough outing vs. the Rays, as he gave up six earned runs in 5 2/3 innings of work. In that outing, he gave up three homers. Before that, he had put together three straight quality starts. Gausman’s ERA for the season is 4.59, along with a record of 3-4. Looking at his home/road splits, he has a record of 2-1 at home with a 3.88 ERA. On the road, he is 1-3 with a 7.28 ERA.

San Diego Padres vs. Toronto Blue Jays MLB Baseball Betting Trends

• The Padres head into the game having gone 6-4 straight-up in their last ten games on the road.
• The Padres they are 6-4 vs. the runline in their previous ten games on the road.
• Conversely, the Blue Jays are 5-5 over their last ten home games (straight-up).
• Furthermore, the Blue Jays have a 5-5 mark vs. the runline across their last ten home games.
• Also, the Padres are 0-3 in their last three games as the favorite. On the other hand, they are 1-2 as the underdog (last 3).
• The Blue Jays have a record of 1-2 across their last three games when favored. As the underdog, they are 2-1 in their last three games.

Padres vs. Blue Jays Prediction: Padres ML +130

Given that the Padres are the underdogs in this one, we really like them to pick up a win on the money line. The payout for the Padres is sitting at +130, and our predicted score is 6-4 in favor of the Padres.

Looking at the starting pitchers, we have Randy Vásquez finishing with more strikeouts than Kevin Gausman. However, our projections have Gausman finishing with a better ERA than Vásquez.

If you’re looking for a parlay, you could look to add that the Padres and Blue Jays will combine for nine runs, as we have the over/under at 8.5.

Today’s MLB Free Pick

MLB Betting Tweet Of The Day

Goodnight, #BlueJays fans 💙

Let’s do it again tomorrow: https://t.co/1L6qzdmNeW pic.twitter.com/9UkRboOQz2

— Toronto Blue Jays (@BlueJays) May 21, 2025

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About Matthew Wiesenfeld

For nearly a two decades the Wiesguy has been helping readers learn and win. Hailing from Toronto, Canada he is a true expert. He is always a little sweet on the underdogs while covering all sports to give you the insight you need to build your bankroll.

Filed Under: MLB Baseball