Free NFL Week 13 Pick: 49ers vs. Bills Odds
Looking for San Francisco 49ers vs. Buffalo Bills free NFL picks & NFL odds? NFL betting sees the 49ers taking on the Bills on Sunday, December 1st at the Highmark Stadium. Cappers Picks provides complimentary NFL Football handicapping picks all NFL season long including all NFL Week 13 games so stay tuned for more FREE NFL predictions like this San Francisco Buffalo matchup.
NFL Handicapping Analysis: Week 13
(5-6) San Francisco 49ers vs. Buffalo Bills (9-2)
Date: Sunday, December 1st
Time: 8:20 ET
Venue: Highmark Stadium, Orchard Park NY
NFL ATS Betting Lines: (BET NOW!) San Francisco +7 | Buffalo -7
NFL Moneyline Odds: San Francisco +258 | Buffalo -327
NFL Betting Total: O/U 44.5
- Live Betting Odds for the upcoming San Francisco 49ers vs. Buffalo Bills Week 13 game!
- Want more NFL football regular season predictions like this 49ers Bills play? Check out our free NFL Week 13 AI Picks for today!
- View our Updated Sportsbook Bonuses for today!
Get ready for a clash of titans in Week 13 as the San Francisco 49ers take on the Buffalo Bills in primetime! This historic rivalry, dating back to the legendary “No Punt Game” of 1992, has seen 13 meetings, with the Bills holding a narrow 7-6 edge in the series.
Their most recent encounter in 2020 ended with Buffalo taking a decisive 34-24 win in San Francisco, led by Josh Allen, while Nick Mullens helmed the 49ers.
Fast forward to this Sunday, and the stakes couldn’t be higher as these two teams meet under the bright lights of Highmark Stadium.
The Bills, sitting pretty at 9-2, have been an absolute juggernaut, boasting a flawless 10-0 December record over their last 10 games.
When looking back over the last three times these two teams have played, the Bills have the leg up at 2-1. The Bills also had the edge vs. the spread in these games, at 2-1.
These games averaged a combined total of 55 points per game leading to an over/under record of 3-0.
San Francisco 49ers
After a week 10 win over the Buccaneers, the 49ers have now dropped two straight, including a 38-10 loss to the Packers in week 12. San Francisco was unable to cover the 6.5-point spread, and they are now 4-7 against the spread this season. They have an average scoring margin of 0 points per game and rank 7th in our NFL power rankings.
Heading into week 13, the 49ers have a 16.5% chance of making the playoffs and a 12.9% chance of winning the NFC West. They are currently 4th in the division with a 5-6 record, including a 1-3 mark in divisional games. San Francisco is 3-3 at home and 2-3 on the road.
San Francisco 49ers Stats
Heading into week 13, the 49ers are 12th in our offensive power rankings, averaging 23.6 points per game, which ranks 13th in the NFL. They are 4th in passing yards per game with 246.2, despite ranking 20th in pass attempts. On the ground, they average 138.4 rushing yards per game, ranking 7th in the league, on 28.5 attempts per game. San Francisco ranks 6th in 3rd-down conversions, with a 44.2% success rate, but they are 21st in red zone conversion percentage, scoring on just 16.7% of their trips.
In week 12, the 49ers struggled offensively, scoring just 10 points in a loss to the Packers. Brandon Allen threw for 199 yards (17/29) with 1 touchdown and 1 interception. Christian McCaffrey was held to 31 yards on 11 carries, while George Kittle led the team with 6 catches for 82 yards and a touchdown. Brock Purdy, who is dealing with a shoulder injury, was limited in practice this week.
Expert NFL Betting Picks
Looking for more NFL betting picks? Check out today’s featured premium plays from CappersPicks handicappers, including sides, totals, and weekly NFL betting packages.
In their 38-10 loss to the Packers, the 49ers’ defense allowed 325 yards and 169 rushing yards on 42 attempts (4.0 per attempt). They gave up two passing touchdowns but held Green Bay to just 156 yards passing. The defense recorded two sacks and allowed the Packers to convert on 46.2% of their third downs.
The 49ers’ run defense struggled, and they also allowed the Packers to score on two of their limited opportunities in the passing game. Despite their struggles, the 49ers’ defense did well in the tackles for loss battle, coming out ahead by a margin of +2.
Buffalo Bills
Buffalo’s 30-21 win over the Chiefs in week 11 extended their winning streak to six games, bringing their record to 9-2. The victory kept the Bills in first place in the AFC East and second in the conference standings. According to our projections, Buffalo has a 100% chance of making the playoffs and winning the division. They are ranked 3rd in our NFL power rankings heading into week 13.
Buffalo is 7-4 against the spread this season, including two straight ATS wins. They covered the 3-point spread against the Chiefs, and the 51 combined points went over the 47-point line. The over has hit in each of the Bills’ last three games.
Buffalo Bills Stats
Heading into week 13, the Bills are 3rd in our offensive power rankings, averaging 29.1 points per game, which ranks 3rd in the NFL. They are 13th in passing yards per game (226.1) and 19th in passing attempts. Josh Allen threw for 262 yards (27/40) with one touchdown and one interception in week 11 against the Chiefs, posting a passer rating of 83.
Buffalo ranks 11th in rushing yards per game, with 119.2, on 27.9 attempts per game. Allen led the team in rushing in week 11, with 55 yards on 12 carries, while Khalil Shakir had 8 receptions for 70 yards.
In their 30-21 win over the Chiefs, the Bills’ defense gave up 181 passing yards and allowed three passing touchdowns. The Bills’ defense did come up with two interceptions, helping to offset the Chiefs’ 69.7% completion percentage. Buffalo’s run defense allowed 78 yards on 17 attempts. The Bills’ defense forced the Chiefs to convert on only 2 of their 4 third down attempts.
Buffalo’s defense gave up 259 total yards in the game. Despite giving up three passing touchdowns, the Bills defended the run well, allowing just 78 yards on 17 attempts. They also forced two interceptions and limited the Chiefs to a 2 of 4 success rate on third down conversions.
San Francisco 49ers vs. Buffalo Bills NFL Football Betting Trends
- The 49ers are 2-3 in their last five games as an underdog.
- Conversely, the Bills are 4-1 ATS in their last five games as a favorite.
- Also, the 49ers are 5-5 ATS in their last ten road games.
- On the other side, the Bills have gone 6-4 across their last ten home games.
- Over the 49ers’ last 3 road games, the over/under record is 2-1.
- The Bills’ have an over/under record of 2-1 in their last 3 games at home.
49ers vs. Bills Line Movement
| Open-ML | Live-ML | Open-Spread | Live-Spread | |
|---|---|---|---|---|
| 49ers | -125 | +257 | -2 | +7 |
| Bills | +105 | -327 | +2 | -7 |
4* Free Week 13 NFL Betting Prediction: Buffalo -7
The Bills are not just winning—they’re covering, going 5-1 ATS in their last six outings. Add in an 8-1 record against NFC opponents over their last nine, and it’s clear Buffalo thrives in inter-conference matchups.
Meanwhile, the 49ers have stumbled, going just 1-4 ATS in their last five games and struggling on the road with a dismal 1-5 ATS in their last six away contests.
The 49ers are also just 3-6 ATS in their last nine against Buffalo, making this an uphill battle for the underdogs.
Our pick against the spread for this week 13 matchup between the 49ers and Bills is to take Buffalo to cover as 7-point favorites at home. We have the Bills winning by a score of 31-17, making them a great pick to cover the spread.
The 49ers, to me, are starting to look like a slow moving dumpster fire. I think that trend continues this week.
For an over/under pick, we like taking the over, with a projected combined score of 49 points. The current O/U line is 44.5 points, making the over a good value pick in this one.
It’s tempting to dream of a shootout reminiscent of that punt-free thriller from ’92, but in today’s game, the Bills’ consistency and dominance make it tough to see the Niners keeping pace.
San Francisco has the heart, but Buffalo has the momentum, and this one could be a statement game for a team with its eyes on the postseason prize. Grab your popcorn—it’s Week 13 NFL football, and it doesn’t get better than this!
Best Sportsbooks For San Francisco 49ers vs. Buffalo Bills NFL Gambling Today!
- 50% Reload Bonuses
- Daily Player Promos
- Live Dealer Casino
- Crypto Deposits
- Same-Game Parlays
- Casino + Poker
- Same-Game Parlays
- Overnight Lines
- Progressive Jackpots
- Reduced-Juice Lines
- 7% Racebook Rebate
- 100% Crypto Bonus
- VIP Cash Rewards
- Live Betting & Props
- High Betting Limits
In Canada? Try Bodog!
San Francisco 49ers vs. Buffalo Bills NFL Betting Tweet Of The Day
GO BILLS
GO BILL
GO BIL
GO BI
GOB
GOBB
GOBBL
GOBBLE
GOBBLES pic.twitter.com/EPsBIBITtN— Buffalo Bills (@BuffaloBills) November 28, 2024
If you’re looking for more NFL picks like this San Francisco 49ers vs. Buffalo Bills matchup we’ll be providing 4* free NFL predictions on the blog all season long, and check out our Experts for guaranteed premium & free NFL Football picks!
Register here for a FREE NFL Football Betting Account Now for Daily Free Picks & More Special NFL Regular Season Offers!
