Free AI NFL Prediction: 49ers at Seahawks Odds
Looking for a free San Francisco 49ers at Seattle Seahawks AI computer prediction? Our NFL prediction model analyzes the matchup, betting odds, trends and available game data to produce today’s NFL computer pick. Scroll down for our 49ers at Seahawks AI pick, projected score and best bet.
San Francisco 49ers at Seattle Seahawks AI Computer Picks & NFL Betting Analysis
- (4-0) San Francisco 49ers at Seattle Seahawks (3-1)
- Date: Sunday, October 11th
- Week: Week 5
- Time: 4:25 PM ET
- Venue: Lumen Field Seattle, WA
- NFL Moneyline Odds: 49ers +133 | Seahawks -157 (Bet Now!)
- NFL ATS Odds: 49ers +3 | Seahawks -3
- NFL Betting Total: O/U: 46.5
CappersPicks uses artificial intelligence (AI) to analyze NFL data, betting odds and matchup trends for our daily computer picks. Our AI prediction model turns that data into free NFL computer predictions, projected scores and best bets. Scroll down for today’s 49ers at Seahawks AI pick.
Offensive NFL Stats From Last Week
| Stat | 49ers | Seahawks |
|---|---|---|
| PPG | 30.5 (2nd) | 26.2 (9th) |
| YPG | 389 (7th) | 347.2 (13th) |
| RUSH YPG | 137.2 (6th) | 110.2 (13th) |
| PASS YPG | 251.8 (8th) | 237 (14th) |
| 3 DOWN % | 57.5 (1st) | 31.1 (27th) |
Defensive NFL Stats From Last Week
| Stat | 49ers | Seahawks |
|---|---|---|
| PPG ALLWD | 16 (3rd) | 18.2 (5th) |
| YPG ALLWD | 308.8 (7th) | 246.8 (1st) |
| RUSH YPG ALLWD | 99.8 (9th) | 102 (11th) |
| PASS YPG ALLWD | 209 (11th) | 144.8 (1st) |
| TO | 3 (7th) | 8 (2nd) |
| SACKS | 6 (10th) | 11 (5th) |
49ers vs. Seahawks Head-to-Head Trends for Our AI Prediction
- In the 2025 Divisional Playoffs, the Seahawks beat the 49ers 41–6 at Lumen Field, covering the spread of -7.0.
- During Week 18 of the 2025 Regular Season, Seattle won against San Francisco 13–3 at Levi’s Stadium, covering the spread of -2.5.
- In Week 1 of the 2025 Regular Season, the 49ers defeated the Seahawks 17–13 at Lumen Field, covering the spread of +2.0.
- In Week 11 of the 2024 Regular Season, the Seahawks won 20–17 at Levi’s Stadium, but the 49ers covered the spread of -6.0.
San Francisco 49ers vs. Seattle Seahawks NFL Betting Trends
Before locking in your pick for the San Francisco 49ers vs. Seattle Seahawks matchup, take a look at some key betting trends. Indeed, both teams have shown strong patterns in specific spots — and these stats could help uncover where the value lies on today’s NFL betting card.
- The 49ers have a perfect 5-0 record against the spread in their last five regular season away games.
- San Francisco is 10-1 straight up in their last 11 regular season games.
- Seattle has won all of their last seven regular season home games straight up.
- Also, the Seahawks are 13-1 straight up in their last 14 regular season games as favorites.
- Additionally, the 49ers are 8-1 straight up in their last nine regular season games after a win.
- The Seahawks have an 8-4 record against the spread in their last 12 regular season games after a win.
49ers Injury Report
| Kyle Juszczyk | Out | Knee |
| Demarcus Robinson | Out (IR) | Ankle |
| Christian Kirk | Out (IR) | Calf |
| Nick Bosa | Questionable | Knee/Calf |
| Brett Toth | Out (IR) | Concussion |
| Brandon Aiyuk | Out | Personal |
| Austen Pleasants | Out (IR) | Knee |
| Darrick Forrest | Out (IR) | Undisclosed |
| Nate Hobbs | Out (IR) | Groin |
| Nick Zakelj | Out (IR) | Elbow |
| Jake Tonges | Out (IR) | Knee |
| Sam Okuayinonu | Out (IR) | Foot |
| Andrew Farmer II | Out (IR) | Back |
| Ricky Pearsall | Out (IR) | Knee |
| Isaac Guerendo | Out (PUP) | Pectoral |
| Mykel Williams | Questionable (PUP) | Knee |
| Nick Martin | Out (IR) | Hamstring |
| Alfred Collins | Out (IR) | Knee |
Seahawks Injury Report
| Chazz Surratt | Questionable | Calf |
| Zach Charbonnet | Questionable (PUP) | Knee |
| Irv Charles | Out (IR) | Undisclosed |
| Anthony Bradford | Out (IR) | Knee |
| Jake Bobo | Out (IR) | Knee |
| Ty Okada | Questionable | Hamstring |
| Terrion Arnold | Out (Commissioner Exempt) | Commissioner Exempt List |
| Robbie Ouzts | Out (IR) | Neck |
| Mason Richman | Out (IR) | Undisclosed |
| Jacardia Wright | Out (IR) | Undisclosed |
| Jadarian Price | Out (IR) | Chest |
| Bud Clark | Out (IR) | Ankle |
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Today’s 49ers at Seahawks AI Computer Pick
NFL Free Score Prediction: 49ers 24 – Seahawks 21 (Bet Now!) Our AI likes 49ers to win by 3.
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49ers at Seahawks Odds for Our AI Computer Prediction
Below are the updated 49ers at Seahawks NFL odds used by our AI prediction model.
Free NFL AI Computer Picks & Predictions
With 20+ years of CappersPicks handicapping data, our AI prediction model analyzes NFL matchups, betting trends and odds to produce free NFL computer picks and score predictions. Check back daily for our latest AI NFL picks, including today’s San Francisco 49ers at Seattle Seahawks AI prediction.
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