Free AI NFL Prediction: 49ers at Colts Odds
If you’re searching for San Francisco 49ers at Indianapolis Colts AI computer NFL football free predictions look no further! This game takes place on Monday, December 22nd at Lucas Oil Stadium, in Indianapolis. At this time, our AI NFL computer prediction model has the gambling analysis, football betting trends, and outcome locked in. In fact, when you’re ready, just scroll down to get the free AI NFL pick.
NFL Handicapping – San Francisco 49ers at Indianapolis Colts AI NFL Football Prediction
- (10-4) San Francisco 49ers at Indianapolis Colts (8-6)
- Date: Monday, December 22nd
- Time: 8:15 PM ET
- Venue: Lucas Oil Stadium Indianapolis, IN
- NFL Moneyline Odds: 49ers -288 | Colts +234 (Bet Now!)
- NFL ATS Odds: 49ers -6.0 | Colts +6.0
- NFL Betting Total: O/U: 46.5
As can be seen, artificial intelligence (AI) is used by CappersPicks.com to sort through vast quantities of data and identify the best outcomes for free computer picks on NFL football betting each day. For one thing, we save you tons of time and energy researching your selections by giving you our daily AI best bets. In fact, scroll down for today’s San Francisco 49ers at Indianapolis Colts AI NFL prediction.
Offensive NFL Stats
| Stat | 49ers | Colts |
|---|---|---|
| PPG | 389 (13th) | 377 (16th) |
| YPG | 6397 (4th) | 5692 (25th) |
| RUSH YPG | 2163 (12th) | 2331 (8th) |
| PASS YPG | 4234 (4th) | 3361 (25th) |
| 3 DOWN % | 42.6 (9th) | 37.9 (16th) |
Defensive NFL Stats
| Stat | 49ers | Colts |
|---|---|---|
| PPG ALLWD | 436 (26th) | 427 (23rd) |
| YPG ALLWD | 5396 (8th) | 6140 (29th) |
| RUSH YPG ALLWD | 2163 (12th) | 2331 (8th) |
| PASS YPG ALLWD | 4234 (4th) | 3361 (25th) |
| TO | 17 (18th) | 26 (9th) |
| SACKS | 37 (12th) | 36 (13th) |
49ers vs. Colts AI Last Five Head To Head Trends
- The Colts have won the last four meetings against the 49ers.
- Each of the last four games between the 49ers and Colts has gone under the total.
- The most recent game between the 49ers and Colts was in 2018, with the Colts winning 23–17.
- The Colts have not lost to the 49ers since at least 2005.
San Francisco 49ers vs. Indianapolis Colts NFL Betting Trends
Before locking in your pick for the San Francisco 49ers vs. Indianapolis Colts matchup, take a look at some key betting trends. Indeed, both teams have shown strong patterns in specific spots — and these stats could help uncover where the value lies on today’s NFL betting card.
- The 49ers are 5-0 against the spread as favorites in their last five regular season games.
- San Francisco is 3-0 straight up in their last three away games.
- The Colts have gone 3-0 against the spread as underdogs in their last three games.
- Indianapolis is 7-1 straight up in their last eight home games.
- Also, the 49ers have hit the over in 5 of their last 7 away games.
- Additionally, the Colts have hit the over in 3 of their last 4 home games.
49ers Injury Report
| Trent Taylor | Out | Undisclosed |
| Fred Warner | Out | Ankle |
| Nick Bosa | Out | Knee |
| Brandon Aiyuk | Out | Knee |
| Patrick Taylor Jr. | Out | Shoulder |
| Yetur Gross-Matos | Questionable | Knee/Hamstring |
| Ben Bartch | Out | Foot |
| Jordan Elliott | Questionable | Knee |
| Tarron Jackson | Out | Neck |
| Sam Okuayinonu | Questionable | Ankle |
| Tre Tomlinson | Out | Undisclosed |
| Jacob Cowing | Out | Hamstring |
| Ricky Pearsall | Questionable | Knee |
| Tatum Bethune | Questionable | Ankle |
| Mykel Williams | Out | Knee |
| Nick Martin | Questionable | Concussion |
| Kurtis Rourke | Questionable | Knee |
| Jakob Robinson | Out</td |
Colts Injury Report
| DeForest Buckner | Questionable | Neck |
| Mike Hilton | Out | Shoulder |
| Braden Smith | Out | Concussion/Neck |
| Chris Lammons | Out | Foot |
| Charvarius Ward | Out | Concussion |
| Daniel Jones | Out | Achilles |
| Ashton Dulin | Out | Hamstring |
| D.J. Montgomery | Out | Undisclosed |
| Salvon Ahmed | Out | Ankle |
| Jacob Phillips | Out | Bicep |
| Sauce Gardner | Questionable | Calf |
| Bernhard Raimann | Questionable | Elbow |
| Blake Freeland | Out | Leg |
| Anthony Richardson Sr. | Out | Eye |
| Daniel Scott | Out | Knee |
| Anthony Gould | Questionable | Foot |
| Spencer Shrader | Out | Knee |
| Jack Wilson | Out | Pectoral |
| Hunter Wohler | Out | Foot |
| Justin Walley</td |
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Today’s Free 49ers at Colts NFL Free AI Pick
NFL Free Score Prediction: 49ers 27 – Colts 20 (Bet Now!) Our AI likes 49ers to win by 7.
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- 1% of your bankroll for 4* or less.
- 2% for 5* and 6*.
- Also, 4% for 7* or higher.
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Odds Comparison: San Francisco 49ers at Indianapolis Colts
Below are the updated San Francisco vs. Indianapolis NFL odds used by our AI prediction model.
20+ Years Handicapping NFL
Most important, with 20 years of handicapping data, our AI picks will deliver accurate predictions and easy-to-use tools to enhance your bets on every NFL football game we can get to. Hopefully you like our San Francisco 49ers at Indianapolis Colts AI NFL prediction today! After all, it’s a free NFL football pick, right? Enjoy!
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