Free AI NFL Prediction: 49ers vs. Bills
If you’re searching for free computer football picks or San Francisco 49ers vs. Buffalo Bills AI NFL Week 13 predictions look no further! This game takes place on Sunday, December 1st at Highmark Stadium in Orchard Park. NY. At this time our AI NFL computer prediction model has the gambling analysis, football betting trends, and outcome locked in. In fact, when you’re ready, just scroll down to get the free AI NFL Sunday Night Football pick.
NFL Handicapping: San Francisco 49ers at Buffalo Bills AI NFL Football Prediction
- Sunday Night Football on NBC
- (5-6) San Francisco 49ers vs. Buffalo Bills (9-2)
- Date: Sunday, December 1st
- Time: 8:20 ET
- Venue: Highmark Stadium Orchard Park, NY
- NFL Moneyline Odds: 49ers +258 | Bills -327 (Bet Now!)
- NFL ATS Odds: 49ers +7 | Bills -7
- NFL Betting Total: O/U: 44.5
As can be seen, artificial intelligence (AI) is used by CappersPicks.com to sort through vast quantities of NFL betting data and identify the best outcomes for free computer picks on NFL playoff football betting each day. For one thing, we save you tons of time, and energy researching your selections by giving you our daily AI best bets. In fact, scroll down for today’s San Francisco 49ers vs. Buffalo Bills AI NFL prediction.
Week 13 Offensive NFL Stats
| Stat | SF | BUF |
|---|---|---|
| PPG | 23.6 (13th) | 29.1 (3rd) |
| YPG | 384.5 (4th) | 345.3 (13th) |
| RUSH YPG | 138.4 (7th) | 119.2 (11th) |
| PASS YPG | 246.2 (4th) | 226.1 (13th) |
| 3 DOWN % | 44.2% (6th) | 42% (9th) |
| RDZ % | 16.7% (21st) | 6.4% (28th) |
Week 13 Defensive NFL Stats
| Stat | SF | BUF |
|---|---|---|
| PPG ALLWD | 23.6 (19th) | 19.5 (7th) |
| YPG ALLWD | 304.3 (6th) | 329.1 (15th) |
| RUSH YPG ALLWD | 110.8 (11th) | 119.1 (13th) |
| PASS YPG ALLWD | 193.5 (6th) | 210.0 (14th) |
| TO | 16 (7th) | 21 (3rd) |
| SCKS | 28 (12th) | 27 (13th) |
San Francisco 49ers vs. Buffalo Bills AI Last Five Head To Head Trends
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- Additionally, the Bills went 3-2 vs. the spread in these matchups.
In terms of the over/under, the 49ers and Bills put together a mark of 4-1 (last 5). Moreover, the Bills have an average scoring differential of 5 in these matchups, combining to average 45 points per game.
San Francisco 49ers vs. Buffalo Bills NFL Betting Trends
- The 49ers are 2-3 in their last five games as an underdog.
- Conversely, the Bills are 4-1 ATS in their last five games as a favorite.
- Also, the 49ers are 5-5 ATS in their last ten road games.
- On the other side, the Bills have gone 6-4 across their last ten home games.
- Over the 49ers’ last 3 road games, the over/under record is 2-1.
- The Bills’ have an over/under record of 2-1 in their last 3 games at home.
San Francisco 49ers Injury Report
| Name | Position | Reason | Status |
|---|---|---|---|
| Jon Feliciano | G | Knee | Out |
| Trent Williams | OT | Ankle | Questionable |
| Javon Hargrave | DL | Triceps | Out |
| Charvarius Ward | CB | Personal | Probable |
| Kevin Givens | DL | Groin | Questionable |
| Dre Greenlaw | LB | Achilles | Questionable |
| Nick Bosa | DL | Hip/oblique | Questionable |
| Mitch Wishnowsky | P | Back | Out |
| Demetrius Flannigan-Fowles | LB | Knee | Questionable |
| Brandon Aiyuk | WR | Knee | Out |
| Jordan Elliott | DT | Concussion | Questionable |
| Elijah Mitchell | RB | Hamstring | Out |
| Aaron Banks | G | Concussion | Questionable |
| Talanoa Hufanga | S | Wrist | Out |
| Ambry Thomas | CB | Forearm | Out |
| Curtis Robinson | LB | Knee | Out |
| Drake Jackson | DL | Knee | Out |
| Brock Purdy | QB | Right Shoulder | Questionable |
| Deommodore Lenoir | CB | Knee | Questionable |
| Dominick Puni | G | Shoulder | Questionable |
| Darrell Luter Jr. | CB | Pelvis | Out |
| Renardo Green | CB | Neck | Questionable |
| Tatum Bethune | LB | Knee | Out |
| Jacob Cowing | WR | Concussion | Probable |
Buffalo Bills Injury Report
| Name | Position | Reason | Status |
|---|---|---|---|
| DaQuan Jones | DT | Foot | Probable |
| Amari Cooper | WR | Wrist | Probable |
| Curtis Samuel | WR | Pectoral | Probable |
| Mack Hollins | WR | Shoulder | Probable |
| Taylor Rapp | S | Foot/shoulder | Probable |
| Reggie Gilliam | FB | Hip | Probable |
| Quintin Morris | TE | Shoulder | Probable |
| Kaiir Elam | CB | Shoulder | Probable |
| Terrel Bernard | LB | Ankle | Probable |
| Casey Toohill | DE | Knee | Probable |
| Dorian Williams | LB | Knee | Probable |
| Travis Clayton | OT | Shoulder | Out |
| DeWayne Carter | DT | Wrist | Questionable |
| Tylan Grable | OT | Groin | Questionable |
| Keon Coleman | WR | Wrist | Questionable |
| Dalton Kincaid | TE | Knee | Questionable |
| Baylon Spector | LB | Calf | Out |
| Tommy Doyle | OT | Undisclosed | Out |
| Spencer Brown | OT | Ankle | Questionable |
| Shane Buechele | QB | Neck | Out |
| Dawuane Smoot | DE | Wrist | Out |
| Matt Milano | LB | Bicep | Questionable |
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Today’s Free San Francisco 49ers at Buffalo Bills NFL Free AI Pick
NFL Free Score Prediction: Bills 27 – 49ers 16 (Bet Now!) Our AI likes Bills to win by 11.
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Odds Comparison: 49ers vs. Bills
Below are the updated San Francisco vs. Buffalo NFL odds that our AI prediction has used for this free NFL football computer pick. (If odds are available at the time of reading, they will display below.)
AI NFL Picks
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Most important, with 20 years of handicapping data, our AI picks will deliver accurate predictions and easy-to-use tools to enhance your bets on every NFL football game we can get to. Hopefully you like our San Francisco 49ers at Buffalo Bills AI NFL prediction today! After all, it’s a free NFL football pick, right? Enjoy!
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