Free AI NFL Prediction: 49ers at Cardinals Odds
If you’re searching for San Francisco 49ers at Arizona Cardinals AI computer NFL football free predictions look no further! This game takes place on Sunday, November 16th at State Farm Stadium, in Arizona. At this time, our AI NFL computer prediction model has the gambling analysis, football betting trends, and outcome locked in. In fact, when you’re ready, just scroll down to get the free AI NFL pick.
NFL Handicapping – San Francisco 49ers at Arizona Cardinals AI NFL Football Prediction
- (6-4) San Francisco 49ers at Arizona Cardinals (3-6)
- Date: Sunday, November 16th
- Time: 4:05 PM ET
- Venue: State Farm Stadium Arizona, AZ
- NFL Moneyline Odds: 49ers -158 | Cardinals +132 (Bet Now!)
- NFL ATS Odds: 49ers -3.0 | Cardinals +3.0
- NFL Betting Total: O/U: 48
As can be seen, artificial intelligence (AI) is used by CappersPicks.com to sort through vast quantities of data and identify the best outcomes for free computer picks on NFL football betting each day. For one thing, we save you tons of time and energy researching your selections by giving you our daily AI best bets. In fact, scroll down for today’s San Francisco 49ers at Arizona Cardinals AI NFL prediction.
Offensive NFL Stats
| Stat | 49ers | Cardinals |
|---|---|---|
| PPG | 389 (13th) | 400 (12th) |
| YPG | 4234 (4th) | 3639 (18th) |
| RUSH YPG | 2163 (12th) | 2451 (7th) |
| PASS YPG | 4234 (4th) | 3639 (18th) |
| 3 DOWN % | 42.6 (9th) | 43 (8th) |
Defensive NFL Stats
| Stat | 49ers | Cardinals |
|---|---|---|
| PPG ALLWD | 436 (26th) | 379 (14th) |
| YPG ALLWD | 5396 (8th) | 5823 (21st) |
| RUSH YPG ALLWD | 2163 (12th) | 2451 (7th) |
| PASS YPG ALLWD | 4234 (4th) | 3639 (18th) |
| TO | 17 (9th) | 17 (9th) |
| SACKS | 37 (12th) | 41 (8th) |
49ers vs. Cardinals AI Last Five Head To Head Trends
- In the 2025 season, the 49ers won against the Cardinals with a score of 16-15 in Week 3.
- The Cardinals covered the spread of +1.5 in their 2025 Week 3 game against the 49ers.
- The total went UNDER 44.5 in the 2025 Week 3 game between the 49ers and Cardinals.
- In the 2024 season, the Cardinals defeated the 49ers with a score of 47-24 in Week 18.
San Francisco 49ers vs. Arizona Cardinals NFL Betting Trends
Before locking in your pick for the San Francisco 49ers vs. Arizona Cardinals matchup, take a look at some key betting trends. Indeed, both teams have shown strong patterns in specific spots — and these stats could help uncover where the value lies on today’s NFL betting card.
- The 49ers are 4-0 straight up in their last 4 games after a loss this season.
- Also, the 49ers have a 3-1 over/under record as favorites in their last 4 games.
- As underdogs, the Cardinals are 3-1 against the spread in their last 4 games.
- The Cardinals have a 6-1 over/under record in home games over their last 7 games.
- Additionally, the 49ers have a 4-2 against the spread record in away games this season.
- The Cardinals are 3-0 against the spread in their last 3 games after a loss.
49ers Injury Report
| Trent Taylor | Out | Undisclosed |
| Fred Warner | Out | Ankle |
| Nick Bosa | Out | Knee |
| Brandon Aiyuk | Out | Knee |
| Patrick Taylor Jr. | Out | Shoulder |
| Yetur Gross-Matos | Out | Knee/Hamstring |
| Tarron Jackson | Out | Neck |
| Brock Purdy | Questionable | Toe |
| Tre Tomlinson | Out | Undisclosed |
| Jacob Cowing | Out | Hamstring |
| Ricky Pearsall | Questionable | Knee |
| Mykel Williams | Out | Knee |
| Alfred Collins | Questionable | Hip |
| Kurtis Rourke | Out | Knee |
| Jakob Robinson | Out | Forearm |
Cardinals Injury Report
| Zay Jones | Out | Achilles |
| James Conner | Out | Foot |
| Justin Jones | Out | Undisclosed |
| Kyler Murray | Out | Foot |
| Jonah Williams | Questionable | Shoulder |
| Mack Wilson Sr. | Out | Ribs |
| L.J. Collier | Out | Knee |
| Sean Murphy-Bunting | Out | Knee |
| Blake Gillikin | Out | Back |
| Simi Fehoko | Out | Wrist |
| Baron Browning | Questionable | Concussion |
| Joey Blount | Out | Neck |
| J.J. Russell | Out | Concussion |
| Bam Knight | Questionable | Ankle |
| BJ Ojulari | Questionable | Knee |
| Trey Benson | Out | Knee |
| Travis Vokolek | Out | Neck |
| Starling Thomas V | Out | Knee |
| Marvin Harrison Jr. | Out | Appendix |
| Xavier |
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Today’s Free 49ers at Cardinals NFL Free AI Pick
NFL Free Score Prediction: 49ers 27 – Cardinals 21 (Bet Now!) Our AI likes 49ers to win by 6.
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- 1% of your bankroll for 4* or less.
- 2% for 5* and 6*.
- Also, 4% for 7* or higher.
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Odds Comparison: San Francisco 49ers at Arizona Cardinals
Below are the updated San Francisco vs. Arizona NFL odds used by our AI prediction model.
20+ Years Handicapping NFL
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