Free AI NFL Prediction: Patriots at Bills Odds
Looking for a free New England Patriots at Buffalo Bills AI computer prediction? Our NFL prediction model analyzes the matchup, betting odds, trends and available game data to produce today’s NFL computer pick. Scroll down for our Patriots at Bills AI pick, projected score and best bet.
New England Patriots at Buffalo Bills AI Computer Picks & NFL Betting Analysis
- (1-2) New England Patriots at Buffalo Bills (3-0)
- Date: Sunday, October 4th
- Week: Week 4
- Time: 1:00 PM ET
- Venue: Highmark Stadium Orchard Park, NY
- NFL Moneyline Odds: Patriots +253 | Bills -309 (Bet Now!)
- NFL ATS Odds: Patriots +6.5 | Bills -6.5
- NFL Betting Total: O/U: 48.5
CappersPicks uses artificial intelligence (AI) to analyze NFL data, betting odds and matchup trends for our daily computer picks. Our AI prediction model turns that data into free NFL computer predictions, projected scores and best bets. Scroll down for today’s Patriots at Bills AI pick.
Offensive NFL Stats From Last Week
| Stat | Patriots | Bills |
|---|---|---|
| PPG | 12 (26th) | 33.7 (1st) |
| YPG | 307 (21st) | 401.7 (4th) |
| RUSH YPG | 109.3 (14th) | 155 (4th) |
| PASS YPG | 197.7 (17th) | 246.7 (7th) |
| 3 DOWN % | 32.5 (27th) | 54.5 (3rd) |
Defensive NFL Stats From Last Week
| Stat | Patriots | Bills |
|---|---|---|
| PPG ALLWD | 17 (4th) | 26 (18th) |
| YPG ALLWD | 278.3 (5th) | 361.3 (25th) |
| RUSH YPG ALLWD | 108.3 (16th) | 107 (15th) |
| PASS YPG ALLWD | 170 (2nd) | 254.3 (26th) |
| TO | 8 (8th) | 5 (5th) |
| SACKS | 7 (7th) | 9 (5th) |
Patriots vs. Bills Head-to-Head Trends for Our AI Prediction
- In Week 15 of the 2025 Regular Season, the Bills won against the Patriots with a score of 35–31 at Gillette Stadium. The game went over the total of 49.5.
- During Week 5 of the 2025 Regular Season, the Patriots defeated the Bills 23–20 at Highmark Stadium. The total was under 49.5.
- In Week 18 of the 2024 Regular Season, the Patriots won 23–16 against the Bills at Gillette Stadium. The game went over the total of 36.5.
- In Week 16 of the 2024 Regular Season, the Bills beat the Patriots 24–21 at Highmark Stadium. The total was under 48.0.
New England Patriots vs. Buffalo Bills NFL Betting Trends
Before locking in your pick for the New England Patriots vs. Buffalo Bills matchup, take a look at some key betting trends. Indeed, both teams have shown strong patterns in specific spots — and these stats could help uncover where the value lies on today’s NFL betting card.
- The Patriots have gone 6-2 straight up in their last 8 regular-season away games.
- New England is 5-3 against the spread in their last 8 regular-season away games.
- Also, the Bills are 8-1 straight up in their last 9 regular-season games as favorites.
- Buffalo has covered the spread in their last 4 regular-season games when favored.
- Additionally, the Bills have a perfect 3-0 straight-up record in their last 3 regular-season home games.
- Buffalo’s over/under record in their last 8 regular-season games is 6-2.
Patriots Injury Report
| Greg Van Roten | Out (IR) | Thigh |
| Harold Landry III | Out (PUP) | Knee |
| Dre’Mont Jones | Questionable | Shoulder |
| A.J. Brown | Out (IR) | Ankle |
| Mike Onwenu | Out (IR) | Ankle |
| Christian Barmore | Questionable | Shoulder |
| Brenden Schooler | Questionable (NFI) | Undisclosed |
| Bryce Baringer | Out (IR) | Undisclosed |
| Julian Hill | Out (IR) | Knee |
| Dell Pettus | Out (IR) | Ankle |
| Craig Woodson | Questionable | Shoulder |
| Marcus Bryant | Out (IR) | Ankle |
| Jeremiah Webb | Out (IR) | Arm |
| Eli Raridon | Questionable | Thigh |
| Quintayvious Hutchins | Out (IR) | Knee |
| Khalil Jacobs | Out (IR) | Undisclosed |
| Myles Montgomery | Out (IR) | Undisclosed |
Bills Injury Report
| Christian Benford | Questionable | Toe |
| Tyrell Shavers | Out (PUP) | Knee |
| T.J. Sanders | Questionable | Illness |
| Dorian Strong | Out (NFI) | Neck |
| Jordan Hancock | Out (IR) | Hamstring |
| Zane Durant | Out (IR) | Undisclosed |
| Ar’maj Reed-Adams | Questionable | Elbow |
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Today’s Patriots at Bills AI Computer Pick
NFL Free Score Prediction: Patriots 20 – Bills 27 (Bet Now!) Our AI likes Bills to win by 7.
NEXT NFL FOOTBALL AI PICK
Not sure what amount to bet on this Patriots at Bills AI NFL prediction? Just like our experts we give star ratings on our plays. So far, these AI NFL computer picks are rated 4*.
- 1% of your bankroll for 4* or less.
- 2% for 5* and 6*.
- Also, 4% for 7* or higher.
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Patriots at Bills Odds for Our AI Computer Prediction
Below are the updated Patriots at Bills NFL odds used by our AI prediction model.
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