Free AI NFL Prediction: Lions at Bills Odds
If you’re searching for Detroit Lions at Buffalo Bills AI computer NFL football free predictions look no further! This Week 2 game takes place on Thursday, September 17th at Highmark Stadium, in Orchard Park. At this time, our AI NFL computer prediction model has the gambling analysis, football betting trends, and outcome locked in. In fact, when you’re ready, just scroll down to get the free AI NFL pick.
NFL Handicapping – Detroit Lions at Buffalo Bills AI NFL Football Prediction
- (1-0) Detroit Lions at Buffalo Bills (1-0)
- Date: Thursday, September 17th
- Week: Week 2
- Time: 8:15 PM ET
- Venue: Highmark Stadium Orchard Park, NY
- NFL Moneyline Odds: Lions +189 | Bills -227 (Bet Now!)
- NFL ATS Odds: Lions +4.5 | Bills -4.5
- NFL Betting Total: O/U: 54.5
As can be seen, artificial intelligence (AI) is used by CappersPicks.com to sort through vast quantities of data and identify the best outcomes for free computer picks on NFL football betting each day. For one thing, we save you tons of time and energy researching your selections by giving you our daily AI best bets. In fact, scroll down for today’s Detroit Lions at Buffalo Bills AI NFL prediction.
Offensive NFL Stats From Last Season
| Stat | Lions | Bills |
|---|---|---|
| PPG | 31 (8th) | 36 (5th) |
| YPG | 369 (12th) | 409 (6th) |
| RUSH YPG | 165 (5th) | 86 (24th) |
| PASS YPG | 204 (14th) | 323 (3rd) |
| 3 DOWN % | 38.5 (13th) | 33.3 (14th) |
Defensive NFL Stats From Last Season
| Stat | Lions | Bills |
|---|---|---|
| PPG ALLWD | 30 (12th) | 31 (13th) |
| YPG ALLWD | 469 (28th) | 381 (22nd) |
| RUSH YPG ALLWD | 91 (11th) | 124 (20th) |
| PASS YPG ALLWD | 378 (29th) | 257 (23rd) |
| TO | 3 (2nd) | 2 (3rd) |
| SACKS | 5 (1st) | 3 (3rd) |
Lions vs. Bills AI Last Five Head To Head Trends
- In the 2024 regular season, the Bills beat the Lions 48–42 at Ford Field, covering the spread of -2.5.
- During the 2022 regular season, Buffalo won against Detroit 28–25 at Ford Field, with the total going under 55.0.
- In the 2018 regular season, the Bills edged out the Lions 14–13 at Highmark Stadium, with the total going under 39.5.
- Back in the 2014 regular season, Buffalo defeated Detroit 17–14 at Ford Field, with the total going under 43.0.
Detroit Lions vs. Buffalo Bills NFL Betting Trends
Before locking in your pick for the Detroit Lions vs. Buffalo Bills matchup, take a look at some key betting trends. Indeed, both teams have shown strong patterns in specific spots — and these stats could help uncover where the value lies on today’s NFL betting card.
- The Lions are 8-3 on the over in their last 11 regular season games.
- Detroit is 4-1 on the over in games with totals of 50 or more in the regular season.
- Buffalo is 6-1 straight up as a favorite in their last 7 regular season games.
- Also, the Bills are 5-1 on the over in their last 6 regular season games.
- Additionally, Buffalo is 4-1 straight up at home in their last 5 regular season games.
- The Lions are 5-2 straight up after a loss in their last 7 regular season games.
Lions Injury Report
| D.J. Reed | Questionable | Foot |
| Payton Turner | Out (IR) | Undisclosed |
| Kerby Joseph | Out (PUP) | Knee |
| Isiah Pacheco | Out (IR) | Back |
| Damone Clark | Out | Undisclosed |
| Cade Mays | Out (IR) | Wrist |
| Brian Branch | Out (PUP) | Achillies |
| Juice Scruggs | Questionable | Knee |
| Christian Izien | Probable | Groin |
| Christian Mahogany | Questionable | Hip |
| Giovanni Manu | Out (NFI) | Undisclosed |
| Mason Miller | Out (IR) | Undisclosed |
| Blake Miller | Questionable | Knee |
| Kendrick Law | Out (IR) | Knee |
Bills Injury Report
| Bradley Chubb | Probable | Thumb |
| Ty Johnson | Questionable | Hamstring |
| Phidarian Mathis | Out | Suspension |
| Terrel Bernard | Questionable | Calf |
| Tyrell Shavers | Out (PUP) | Knee |
| Cole Bishop | Questionable | Knee/Groin |
| T.J. Sanders | Questionable | Knee/Illness |
| Dorian Strong | Out (NFI) | Neck |
| Jordan Hancock | Probable | Quad |
| Zane Durant | Out (IR) | Undisclosed |
View the NFL Cappers whose PICKS are ON FIRE! Click here!
Today’s Free Lions at Bills NFL Free AI Pick
NFL Free Score Prediction: Lions 27 – Bills 34 (Bet Now!) Our AI likes Bills to win by 7.
NEXT NFL FOOTBALL AI PICK
Not sure what amount to bet on this Lions at Bills AI NFL prediction? Just like our experts we give star ratings on our plays. So far, these AI NFL computer picks are rated 4*.
- 1% of your bankroll for 4* or less.
- 2% for 5* and 6*.
- Also, 4% for 7* or higher.
Expert NFL Betting Picks
Looking for more NFL betting picks? Check out today’s featured premium plays from CappersPicks handicappers, including sides, totals, and weekly NFL betting packages.
Today’s NFL Football Sportsbook Offers
Bet on this Detroit Lions at Buffalo Bills AI prediction with our top recommended online sportsbooks & NFL football betting apps. We review and rank the best football gambling sites for you:
- 50% Reload Bonuses
- Daily Player Promos
- Live Dealer Casino
- Crypto Deposits
- Same-Game Parlays
- Casino + Poker
- Same-Game Parlays
- Overnight Lines
- Progressive Jackpots
- Reduced-Juice Lines
- 7% Racebook Rebate
- 100% Crypto Bonus
- VIP Cash Rewards
- Live Betting & Props
- High Betting Limits
Detroit Lions vs. Buffalo Bills Betting
If you like to bet on NFL football, the smart thing to do would be to use our NFL betting tips to learn everything you’ll need to know about making money while gambling on the Detroit Lions vs. Buffalo Bills with our NFL football betting guide. Check out our favorite online sportsbooks! Bovada has fast & free payouts! Founded in 2011, they’re an industry leader, and a trusted source for gaming entertainment for 100K customers. They accept Bitcoin, Bitcoin SV, Bitcoin Cash, Litecoin, & Ethereum. Visit Bovada Today!
Odds Comparison: Detroit Lions at Buffalo Bills
Below are the updated Detroit vs. Buffalo NFL odds used by our AI prediction model.
20+ Years Handicapping NFL
Most important, with 20 years of handicapping data, our AI picks will deliver accurate predictions and easy-to-use tools to enhance your bets on every NFL football game we can get to. Hopefully you like our Detroit Lions at Buffalo Bills AI NFL prediction today! After all, it’s a free NFL football pick, right? Enjoy!
Additionally, you can register here for a FREE NFL football picks account now for daily picks & more special offers! After that, check us out on Linktr.ee!
