Free AI NFL Prediction: Cardinals at 49ers Odds
If you’re searching for Arizona Cardinals at San Francisco 49ers AI computer NFL football free predictions look no further! This Week 3 game takes place on Sunday, September 27th at Levi’s Stadium, in Santa Clara. At this time, our AI NFL computer prediction model has the gambling analysis, football betting trends, and outcome locked in. In fact, when you’re ready, just scroll down to get the free AI NFL pick.
NFL Handicapping – Arizona Cardinals at San Francisco 49ers AI NFL Football Prediction
- (1-1) Arizona Cardinals at San Francisco 49ers (2-0)
- Date: Sunday, September 27th
- Week: Week 3
- Time: 4:05 PM ET
- Venue: Levi’s Stadium Santa Clara, CA
- NFL Moneyline Odds: Cardinals +332 | 49ers -427 (Bet Now!)
- NFL ATS Odds: Cardinals +8.5 | 49ers -8.5
- NFL Betting Total: O/U: 47.5
As can be seen, artificial intelligence (AI) is used by CappersPicks.com to sort through vast quantities of data and identify the best outcomes for free computer picks on NFL football betting each day. For one thing, we save you tons of time and energy researching your selections by giving you our daily AI best bets. In fact, scroll down for today’s Arizona Cardinals at San Francisco 49ers AI NFL prediction.
Offensive NFL Stats From Last Week
| Stat | Cardinals | 49ers |
|---|---|---|
| PPG | 16.5 (18th) | 31 (4th) |
| YPG | 272 (22nd) | 380.5 (7th) |
| RUSH YPG | 93 (22nd) | 134.5 (8th) |
| PASS YPG | 179 (23rd) | 246 (8th) |
| 3 DOWN % | 34.6 (19th) | 63.2 (2nd) |
Defensive NFL Stats From Last Week
| Stat | Cardinals | 49ers |
|---|---|---|
| PPG ALLWD | 22.5 (11th) | 10 (3rd) |
| YPG ALLWD | 324.5 (14th) | 287 (10th) |
| RUSH YPG ALLWD | 121.5 (22nd) | 112 (17th) |
| PASS YPG ALLWD | 203 (12th) | 175 (8th) |
| TO | 3 (4th) | 2 (5th) |
| SACKS | 4 (5th) | 4 (5th) |
Cardinals vs. 49ers AI Last Five Head To Head Trends
- In Week 3 of the 2025 regular season, the Cardinals played at Levi’s Stadium and lost to the 49ers with a score of 15–16. The Cardinals covered the spread of -1.5, and the total went UNDER 44.5.
- During Week 11 of the 2025 regular season, the 49ers visited the Cardinals and won 41–22. The 49ers covered the spread of -3.5, and the total went OVER 48.5.
- In Week 18 of the 2024 regular season, the 49ers played at State Farm Stadium and lost to the Cardinals 24–47. The Cardinals covered the spread of -5.0, and the total went OVER 42.5.
- In Week 5 of the 2024 regular season, the Cardinals visited Levi’s Stadium and won 24–23. The 49ers covered the spread of +7.0, and the total went UNDER 49.0.
Arizona Cardinals vs. San Francisco 49ers NFL Betting Trends
Before locking in your pick for the Arizona Cardinals vs. San Francisco 49ers matchup, take a look at some key betting trends. Indeed, both teams have shown strong patterns in specific spots — and these stats could help uncover where the value lies on today’s NFL betting card.
- The 49ers are 8-0 straight up as favorites in their last 8 regular season games.
- Also, San Francisco is 8-0 against the spread as favorites in their last 8 regular season games.
- The Cardinals have gone 8-6 on the over/under as underdogs in their last 14 regular season games.
- Arizona is 5-9 against the spread as underdogs in their last 14 regular season games.
- Additionally, the 49ers are 4-1 against the spread in their last 5 home games in the regular season.
- The Cardinals are 4-4 on the over/under in their last 8 away games in the regular season.
Cardinals Injury Report
| Andrew Billings | Questionable | Knee |
| James Conner | Out (IR) | Foot |
| Zach Carter | Out (IR) | Knee |
| Joey Blount | Out (IR) | Neck |
| Garrett Williams | Questionable | Achilles |
| Trey Benson | Out (IR) | Knee |
| Tip Reiman | Out (PUP) | Ankle |
| Max Melton | Questionable | Toe |
| Will Johnson | Questionable | Neck |
| Kitan Crawford | Out (IR) | Ankle |
| Chase Bisontis | Out (IR) | Knee |
| Kaleb Proctor | Out (IR) | Knee |
| Jameson Geers | Out (IR) | Undisclosed |
49ers Injury Report
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| Demarcus Robinson | Out | Ankle |
| Christian Kirk | Out (IR) | Calf |
| Brett Toth | Out (IR) | Concussion |
| Brandon Aiyuk | Out | Personal |
| Austen Pleasants | Out (IR) | Knee |
| Darrick Forrest | Out (IR) | Undisclosed |
| Nate Hobbs | Out (IR) | Groin |
| Nick Zakelj | Out (IR) | Elbow |
| Jack Jones | Questionable | Foot |
| Jake Tonges | Out (IR) | Knee |
| Sam Okuayinonu | Out (IR) | Foot |
| Andrew Farmer II | Out (IR) | Back |
| Ricky Pearsall | Out (IR) | Knee |
| Isaac Guerendo | Out (PUP) | Pectoral |
| Mykel Williams | Out (PUP) | Knee |
| Nick Martin | Out (IR) | Hamstring |
| Alfred Collins | Out (IR) | Knee |
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Today’s Free Cardinals at 49ers NFL Free AI Pick
NFL Free Score Prediction: Cardinals 17 – 49ers 28 (Bet Now!) Our AI likes 49ers to win by 11.
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- 1% of your bankroll for 4* or less.
- 2% for 5* and 6*.
- Also, 4% for 7* or higher.
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Odds Comparison: Arizona Cardinals at San Francisco 49ers
Below are the updated Arizona vs. San Francisco NFL odds used by our AI prediction model.
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Most important, with 20 years of handicapping data, our AI picks will deliver accurate predictions and easy-to-use tools to enhance your bets on every NFL football game we can get to. Hopefully you like our Arizona Cardinals at San Francisco 49ers AI NFL prediction today! After all, it’s a free NFL football pick, right? Enjoy!
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