Free AI NFL Prediction: Cardinals at 49ers Odds
If you’re searching for Arizona Cardinals at San Francisco 49ers AI computer NFL football free predictions look no further! This game takes place on Sunday, September 21st at Levi’s Stadium, in San Francisco. At this time, our AI NFL computer prediction model has the gambling analysis, football betting trends, and outcome locked in. In fact, when you’re ready, just scroll down to get the free AI NFL pick.
NFL Handicapping – Arizona Cardinals at San Francisco 49ers AI NFL Football Prediction
- (2-0) Arizona Cardinals at San Francisco 49ers (2-0)
- Date: Sunday, September 21st
- Time: 4:25 PM ET
- Venue: Levi’s Stadium San Francisco, CA
- NFL Moneyline Odds: Cardinals +108 | 49ers -127 (Bet Now!)
- NFL ATS Odds: Cardinals +1.5 | 49ers -1.5
- NFL Betting Total: O/U: 43.5
As can be seen, artificial intelligence (AI) is used by CappersPicks.com to sort through vast quantities of data and identify the best outcomes for free computer picks on NFL football betting each day. For one thing, we save you tons of time and energy researching your selections by giving you our daily AI best bets. In fact, scroll down for today’s Arizona Cardinals at San Francisco 49ers AI NFL prediction.
Offensive NFL Stats
| Stat | Cardinals | 49ers |
|---|---|---|
| PPG | 400 (12th) | 389 (13th) |
| YPG | 6090 (13th) | 6397 (6th) |
| RUSH YPG | 2451 (7th) | 2163 (12th) |
| PASS YPG | 3639 (18th) | 4234 (4th) |
| 3 DOWN % | 43 (8th) | 42.6 (9th) |
Defensive NFL Stats
| Stat | Cardinals | 49ers |
|---|---|---|
| PPG ALLWD | 379 (14th) | 436 (26th) |
| YPG ALLWD | 5823 (21st) | 5396 (8th) |
| RUSH YPG ALLWD | 2451 (7th) | 2163 (12th) |
| PASS YPG ALLWD | 3639 (18th) | 4234 (4th) |
| TO | 17 (18th) | 17 (18th) |
| SACKS | 41 (8th) | 37 (12th) |
Cardinals vs. 49ers AI Last Five Head To Head Trends
- In their last meeting on January 5, 2025, the Cardinals defeated the 49ers 47–24, covering the spread of -5.0.
- The game on October 6, 2024, ended with the Cardinals winning 24–23, but the 49ers covered the spread of +7.0.
- The total has gone over in 4 of the last 5 games between the Cardinals and 49ers.
- At Levi’s Stadium on October 1, 2023, the 49ers won 35–16, covering the spread of +14.5.
Arizona Cardinals vs. San Francisco 49ers NFL Betting Trends
Before locking in your pick for the Arizona Cardinals vs. San Francisco 49ers matchup, take a look at some key betting trends. Indeed, both teams have shown strong patterns in specific spots — and these stats could help uncover where the value lies on today’s NFL betting card.
- The Cardinals have gone 3-0 straight up in their last three regular season games.
- Also, the Cardinals are 4-3 straight up as underdogs in their last seven regular season games.
- The Cardinals have hit the over in five of their last seven regular season games.
- The 49ers are 8-3 against the spread as favorites in their last 11 regular season games.
- Additionally, the 49ers have hit the over in four of their last five regular season games.
- The 49ers are 5-3 straight up as favorites in their last eight regular season games.
Cardinals Injury Report
| Player | Status | Injury |
|---|---|---|
| Will Hernandez (G) | Questionable | Knee |
| Justin Jones (DT) | Out | Undisclosed |
| Bilal Nichols (DT) | Out | Neck |
| L.J. Collier (DL) | Questionable | Knee |
| Sean Murphy-Bunting (CB) | Out | Knee |
| Trishton Jackson (WR) | Out | Thumb |
| Joey Blount (S) | Out | Neck |
| J.J. Russell (ILB) | Out | Concussion |
| BJ Ojulari (OLB) | Out | Knee |
| Garrett Williams (CB) | Questionable | Knee |
| Starling Thomas V (CB) | Out | Knee |
| Tip Reiman (TE) | Questionable | Foot |
49ers Injury Report
<td
| Player | Status | Injury |
|---|---|---|
| Kyle Juszczyk | Questionable | Concussion |
| Demarcus Robinson | Out | Suspended |
| George Kittle | Out | Hamstring |
| Trent Taylor | Out | Undisclosed |
| Siran Neal | Questionable | Head |
| Kevin Givens | Out | Pectoral |
| Jauan Jennings | Questionable | Ankle |
| Brandon Aiyuk | Out | Knee |
| Patrick Taylor Jr. | Out | Shoulder |
| Ben Bartch | Out | Ankle |
| Isaac Alarcón | Out | Suspension |
| Tarron Jackson | Out | Neck |
| Brock Purdy | Doubtful |
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Today’s Free Cardinals at 49ers NFL Free AI Pick
NFL Free Score Prediction: Cardinals 26 – 49ers 23 (Bet Now!) Our AI likes Cardinals to win by 3.
NEXT NFL FOOTBALL AI PICK
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Odds Comparison: Arizona Cardinals at San Francisco 49ers
Below are the updated Arizona vs. San Francisco NFL odds used by our AI prediction model.
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