Free NCAAF Pick: Cowboys vs. Buffaloes Odds
Looking for Wyoming Cowboys vs. Colorado Buffaloes Free NCAA Week 4 picks & NCAA odds? NCAAF betting sees the Cowboys taking on the Buffaloes on 9/20 at Folsom Field, in Colorado. Cappers Picks provides complimentary expert handicapping picks on all NCAA football matchups all season long so stay tuned for more FREE daily NCAAF predictions like this Cowboys Buffaloes free pick.
2025 NCAAF Handicapping – Wyoming Cowboys vs Colorado Buffaloes
(2-1) Wyoming Cowboys vs. Colorado Buffaloes (1-2)
Date: Sep 20, 2025
Time: 10:15 PM ET
Venue: Folsom Field in Colorado, CO
NCAAF Moneyline Odds: Cowboys +385 | Buffaloes -532 (Bet Now!)
Today’s NCAAF Spread Betting Odds: Cowboys +13.5 | Buffaloes -13.5
NCAAF Football Gambling Total: O/U: 44.5
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Cowboys vs. Buffaloes Gameday
On Saturday, September 20, 2025, the Wyoming Cowboys visit the Colorado Buffaloes at Folsom Field in Boulder, CO. The game kicks off at 10:15 PM and will air on ESPN. This is week 4 of the 2025 regular season, and both teams are eager for a win.
The Wyoming Cowboys hold a 2-1 record this season. They started strong with wins against Akron and Northern Iowa, but they stumbled against Utah. The Cowboys are looking to bounce back from that loss.
Meanwhile, the Colorado Buffaloes have a 1-2 record. They won against Delaware but lost to Georgia Tech and Houston. The Buffaloes aim to improve their standing with a win at home.
Both teams are currently unranked, and this game is crucial for gaining momentum. Wyoming is part of the Mountain West Conference, while Colorado plays in the Big 12. Fans can expect an exciting showdown under the lights.
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It’s Week 4, Wyoming Cowboys vs. Colorado Buffaloes, hopefully we get a great matchup.
Wyoming Cowboys vs. Colorado Buffaloes Odds & Last 5
Interestingly, the odds show Wyoming as the underdog with a moneyline of +374. On the other hand, Colorado stands at -495, making them the favorite. The spread favors Colorado by 13.5 points.
In their last game, Wyoming struggled against Utah, losing 31-6. They had difficulty moving the ball, with only 108 passing yards and 122 rushing yards. This week, they hope to improve those numbers.
Meanwhile, Colorado lost to Houston 36-20 in their last outing. Despite having more passing yards, they could not keep up with Houston’s rushing attack. The Buffaloes look to tighten their defense and secure a win at home.
Buffaloes Stats
To begin, the Colorado Buffaloes have shown a mixed performance this season. They rank 57th in points scored, with 71 points so far. Their passing game is ranked 74th, with 630 yards, while rushing is at 90th with 377 yards.
Meanwhile, their defense has been solid in some areas. They rank 10th in sacks with five and are 3rd in interceptions and fumbles recovered, with two and three, respectively. However, they have allowed 70 points, placing them 55th in points against.
In recent games, the Buffaloes have had ups and downs. They secured a win against Delaware, 31-7, but faced losses to Houston and Georgia Tech. Their quarterbacks, Ryan Staub and Kaidon Salter, have contributed with 361 and 261 passing yards, respectively.
Finally, injuries could impact their upcoming games. Several players, including Samuel Okunlola and Jehiem Oatis, are uncertain to play due to undisclosed issues. This could affect their performance on both offense and defense.
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Cowboys Stats
The Wyoming Cowboys’ offense has shown some ups and downs this season. They rank 73rd in points for with 47 points, and their passing game is 91st with 558 yards. However, their rushing attack is slightly better, ranking 62nd with 477 yards.
Next, the Cowboys’ defense has been a strong point, allowing only 38 points, which ranks them 24th. They are also impressive in creating turnovers, with 3 interceptions and 1 fumble recovery, ranking 4th and 5th, respectively. Additionally, their 6 sacks place them 9th in that category.
In recent games, Wyoming had a tough loss to Utah, 31-6, where they struggled with only 108 passing yards. However, they had a solid win against Northern Iowa, 31-7, with 190 passing yards and 189 rushing yards. Their season opener was a defensive battle, winning 10-0 against Akron with 260 passing yards.
Finally, key players for Wyoming include quarterback Kaden Anderson with 535 passing yards and 3 touchdowns. On the ground, Sam Scott leads with 203 rushing yards and 1 touchdown. Chris Durr stands out in the receiving corps with 284 yards and 2 touchdowns, making him a critical target.
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Cowboys vs. Buffaloes QB Matchup
Kaidon Salter is one of the top quarterbacks for Colorado Buffaloes this season. He has played in two games, throwing for 261 passing yards. Although he has only one passing touchdown, he has managed to avoid any interceptions so far.
Ryan Staub, another key quarterback for Colorado, has shown his skills in two games. He has thrown for 361 passing yards and three touchdowns. However, he has also thrown two interceptions, which might be a concern moving forward.
On the other side, Kaden Anderson leads the Wyoming Cowboys as their top quarterback. Over three games, he has accumulated 535 passing yards and three touchdowns. He has also thrown two interceptions, which matches Staub’s record.
Landon Sims, another quarterback for Wyoming, has seen limited action with only one game under his belt. He managed just 23 passing yards and did not throw any touchdowns or interceptions. His fantasy points are quite low, reflecting his limited playtime.
Wyoming Cowboys vs. Colorado Buffaloes Football Betting Trends
- Wyoming is 6-0 against the spread in their last 6 games after a loss.
- Additionally, Wyoming is 6-2 against the spread as an underdog in their last 8 games.
- Wyoming has gone 4-1 against the spread in their last 5 away games.
- Colorado is 5-0 straight up in their last 5 games after a loss.
- Also, Colorado is 8-3 against the spread in their last 11 home games.
- Colorado is 5-2 against the spread as a favorite in their last 7 games.
Cowboys vs Buffaloes Prediction: Under 44.5
The Wyoming Cowboys have been stout defensively, surrendering just 38 points across three games. Their offense hasn’t kept the same pace, producing only 47 points, which shows why their contests tend to lean low scoring.
Colorado hasn’t exactly been firing on all cylinders either, with 71 points in three games while allowing 70. That combination suggests their matchups have been competitive but not overly explosive.
Historically, these programs haven’t met often — just once since 2009, a 24-0 Colorado win — and that defensive outcome lines up with current trends.
It’s also worth noting that both defenses have held up well in early-season non-conference spots. Wyoming especially thrives in slower-paced, grind-it-out games, and Colorado’s middling offensive production isn’t likely to change that script.
With the total sitting at 44.5, the under appears to be the sharper side. Expect a defensive battle where every possession feels magnified and points come at a premium.
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NCAAF Betting Tweet Of The Day
Avalanche in the stands 🥶 pic.twitter.com/WdCv8r3GU6
— Colorado Buffaloes Football (@CUBuffsFootball) September 18, 2025
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