Free NCAAF Pick: Orange vs. Fighting Irish Odds
Looking for Syracuse Orange vs. Notre Dame Fighting Irish Free NCAA Week 13 picks & NCAA odds? NCAAF betting sees the Orange taking on the Fighting Irish on 11/22 at Notre Dame Stadium, in Notre Dame. Cappers Picks provides complimentary expert handicapping picks on all NCAA football matchups all season long so stay tuned for more FREE daily NCAAF predictions like this Orange Fighting Irish free pick.
2025 NCAAF Handicapping – Syracuse Orange vs Notre Dame Fighting Irish
(3-7) Syracuse Orange vs. Notre Dame Fighting Irish (8-2)
Date: Nov 22, 2025
Time: 3:30 PM ET
Venue: Notre Dame Stadium in Notre Dame, IN
NCAAF Moneyline Odds: Orange N/A | Fighting Irish N/A (Bet Now!)
Today’s NCAAF Spread Betting Odds: Orange +35.5 | Fighting Irish -35.5
NCAAF Football Gambling Total: O/U: 50.5
Here’s why I’m backing the bet below in my Orange Fighting Irish free pick & gambling prediction for this matchup.
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Orange vs. Fighting Irish Gameday
It’s Week 13 of the 2025 regular season, and all eyes turn to Notre Dame Stadium as the Syracuse Orange visit the Notre Dame Fighting Irish on November 22 at 3:30 PM on NBC.
Notre Dame enters as a surging top-10 program, while Syracuse arrives searching for anything to stop a season-defining slide.
Syracuse sits at 3-7 and is riding a six-game losing streak, most recently falling 38-10 to Miami. Consistency has been an issue on both sides of the ball, and injuries have only made matters tougher for the Orange.
Notre Dame counters with an 8-2 record and an eight-game win streak, highlighted by last week’s 37-15 win over Pittsburgh. Ranked ninth in both major polls, the Irish continue to look every bit like a New Year’s Six contender.
Notre Dame has historically controlled this matchup, including a 41-24 win in 2022. Syracuse hopes to flip the narrative, but the path won’t be easy in South Bend.
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It’s Week 13, Syracuse Orange vs. Notre Dame Fighting Irish, hopefully we get a great matchup.
Syracuse Orange vs. Notre Dame Fighting Irish Odds & Last 5
Syracuse enters as a massive underdog at +35.0 on the spread, while Notre Dame is favored at -35.0. Oddsmakers expect the Irish to control this game from the start.
Syracuse has struggled heavily in recent weeks, dropping six straight, including the 38-10 loss to Miami where their offense managed only 124 passing yards.
Notre Dame is on the opposite trajectory, winning eight straight.
Their most recent effort was a strong 37-15 showing against Pittsburgh, backed by balanced production on the ground and through the air.
Fighting Irish Stats
Notre Dame has been one of the most efficient offenses in the country, posting 385 total points to rank 11th nationally. Their 1,954 rushing yards rank 28th, giving them a reliable ground punch to complement their passing attack.
Defensively, the Irish remain disruptive with 28 sacks (8th nationally) and 17 interceptions (18th). Their ability to control the line of scrimmage and generate takeaways has fueled their midseason surge.
Recent wins over Pittsburgh and Navy highlight their balance. Against Pitt, the Irish posted 387 total yards, while their defense dominated Navy by allowing only 22 passing yards in a 49-10 victory.
CJ Carr leads the offense with 2,487 passing yards and 21 touchdowns, while Jeremiyah Love has been explosive on the ground with 1,135 yards and 14 touchdowns.
Despite a few injuries, Notre Dame continues to operate at a high level on both sides.
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Orange Stats
Syracuse ranks 82nd in points scored with 223, and their passing game sits 54th at 2,447 yards. Their rushing output has lagged behind at 1,178 yards, ranking 108th nationally.
Defensively, the Orange have struggled, allowing 315 points to rank 123rd. Still, they’ve flashed playmaking ability with 18 sacks (18th) and five interceptions (6th).
Their recent 38-10 loss to Miami was another tough outing, marked by two interceptions and limited offensive production.
Injuries to key players such as Steve Angeli and Tyshawn Russell further thin the rotation.
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Orange vs. Fighting Irish QB Matchup
CJ Carr leads Notre Dame with 2,487 passing yards and 21 touchdowns through 10 games, ranking among the nation’s top producers at the position. Backup Kenny Minchey has added 130 yards across three appearances.
Steve Angeli has thrown for 1,352 yards and 10 touchdowns for Syracuse, though injuries have limited his availability.
Rickie Collins has contributed 1,007 yards and six touchdowns but has also thrown 10 interceptions, reflecting the volatility in the Orange passing game.
Syracuse Orange vs. Notre Dame Fighting Irish bottom line: Notre Dame’s balance, physicality, and turnover production should overwhelm a struggling Syracuse team early.
Syracuse Orange vs. Notre Dame Fighting Irish Football Betting Trends
- Syracuse is 4-1 against the spread in their last 5 away games.
- Also, the total has gone over in 4 of Syracuse’s last 6 away games.
- Syracuse is 10-5-1 on the over/under as an underdog in their last 16 games.
- Notre Dame is 18-2 straight up as a favorite in their last 20 games.
- Additionally, Notre Dame is 12-4 against the spread after a win in their last 16 games.
- The total has gone over in 17 of Notre Dame’s last 26 games as a favorite.
Orange Fighting Irish Free Pick: Notre Dame -35
Here is my Fighting Irish Orange free pick. Notre Dame has been extremely dependable when laying points, stacking an 18-2 straight-up record as a favorite in their last 20 chances.
They’ve dominated these types of matchups by controlling tempo early and leaning on their physicality late, which is exactly what you want when backing a big number. Playing in South Bend only strengthens their edge.
Syracuse comes in limping with a 3-7 record and a shaky 1-3 mark on the road, which raises serious concerns about their ability to keep this competitive. Their offense has struggled to sustain drives, and facing a Notre Dame defense that has allowed just 184 points — ranking 64th nationally — makes the task even tougher.
The Orange have shown flashes, but consistency has been nonexistent.
My system tells me Notre Dame’s dominance as a favorite and Syracuse’s road woes make this -35 spread completely justifiable.
Notre Dame’s defense should control the line of scrimmage, while their balanced offense steadily stretches the lead throughout. Syracuse simply hasn’t shown enough firepower to trade punches for four quarters against a team this complete.
With the Irish rolling at home and the Orange struggling in every key area, Notre Dame -35 is the pick.
Today’s NCAAF Free Pick
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NCAAF Betting Tweet Of The Day
Notre Dame Man ☘️
Marcus Freeman has been named a semifinalist for the George Munger Coach of the Year Award ☘️#GoIrish☘️ | @MaxwellFootball | @Marcus_Freeman1 pic.twitter.com/V296ERFrlu
— Notre Dame Football (@NDFootball) November 19, 2025
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