Free NCAAF Pick: Spartans vs. Trojans Odds
Looking for Michigan State Spartans vs. USC Trojans Free NCAA Week 4 picks & NCAA odds? NCAAF betting sees the Spartans taking on the Trojans on 9/20 at Los Angeles Memorial Coliseum, in USC. Cappers Picks provides complimentary expert handicapping picks on all NCAA football matchups all season long so stay tuned for more FREE daily NCAAF predictions like this Spartans Trojans free pick.
2025 NCAAF Handicapping – Michigan State Spartans vs USC Trojans
(3-0) Michigan State Spartans vs. USC Trojans (3-0)
Date: Sep 20, 2025
Time: 11:00 PM ET
Venue: Los Angeles Memorial Coliseum in USC, CA
NCAAF Moneyline Odds: Spartans +528 | Trojans -790 (Bet Now!)
Today’s NCAAF Spread Betting Odds: Spartans +17.5 | Trojans -17.5
NCAAF Football Gambling Total: O/U: 55.5
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Spartans vs. Trojans Gameday
First, the Michigan State Spartans head to Los Angeles for a night game against the USC Trojans. This Week 4 game of the 2025 Regular Season takes place at the Los Angeles Memorial Coliseum. Fans can catch the action live on FOX at 11:00 PM.
Currently, the Spartans hold a 3-0 record. They have shown strength at home but have yet to test their skills on the road. So, this game marks their first road challenge of the season.
Meanwhile, USC Trojans also boast a 3-0 record. Ranked #25 in the AP poll, USC has defended their home turf successfully this season. They come off a strong win against Purdue Boilermakers, adding to their momentum.
Overall, both teams aim to extend their win streak to four games. With both teams competing in the Big Ten, this game could have implications for conference standings. It will be interesting to see which team maintains their perfect record after this matchup.
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It’s Week 4, Michigan State Spartans vs. USC Trojans, hopefully we get a great matchup.
Michigan State Spartans vs. USC Trojans Odds & Last 5
To begin, the odds favor USC with a moneyline of -811, while Michigan State stands at +552. This spread reflects a prediction of a significant 17.5-point difference. Both teams have strong starts, but the odds suggest USC might have the edge.
Looking back at Michigan State’s previous games, they have shown offensive strength. They scored over 40 points in two of their wins. Yet, they have not played an away game, which will test their resilience on the road.
Meanwhile, USC has been impressive at home, scoring 73 points against Missouri State. Their recent win at Purdue showed their ability to succeed on the road. This game will reveal if they can continue their winning ways at home.
Trojans Stats
To begin, the USC Trojans’ offense is on fire this season. They rank 2nd in points scored with 165 and 6th in passing yards with 1,092. Their rushing game is solid too, ranking 14th with 721 yards.
Next, their defense is making a mark as well. The Trojans lead in sacks with 14 and rank 7th in interceptions with 6. They have only allowed 50 points, placing them 35th in points against.
Recently, the Trojans have been unstoppable. They won their last three games, scoring over 30 points each time. Their most recent victory was a 33-17 win against Purdue.
On the injury front, some players are uncertain for the next game. Key players like Prophet Brown and Prince Strachan are dealing with injuries. This might impact their performance, but the Trojans have depth to rely on.
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Spartans Stats
The Michigan State Spartans have shown a strong offensive presence this season. They have scored 106 points, ranking 30th overall. Their passing game has accumulated 656 yards, placing them 68th, while their rushing attack stands at 509 yards, ranking 57th.
In their recent games, Michigan State has been on a winning streak. They secured victories against Youngstown State, Boston College, and Western Michigan. Notably, their defense held Western Michigan to just 6 points, showcasing their ability to control the game.
Quarterback Aidan Chiles has been a standout player for the Spartans. He has thrown for 656 yards and 6 touchdowns in three games. On the ground, Makhi Frazier leads with 206 rushing yards, although he is currently dealing with an injury.
Finally, the Spartans’ defense has been effective, with 6 sacks and 2 interceptions this season. They rank 9th in sacks and 3rd in interceptions. However, they face some injury concerns, with several key players listed as questionable for their next game.
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Spartans vs. Trojans QB Matchup
Jayden Maiava has been a standout for USC this season. In just three games, he has thrown for 989 yards, ranking him first on his team and fifth in the league. Additionally, he has thrown six touchdowns without any interceptions, which is quite impressive.
Maiava’s performance has also been reflected in his fantasy points. He has accumulated 78 points, placing him first on his team and 18th in the league. His ability to avoid turnovers and rack up yards makes him a key player for the Trojans.
On the other side, Aidan Chiles leads the Michigan State Spartans. Over three games, he has passed for 656 yards, which ranks him first on his team and 56th in the league. Chiles has also thrown six touchdowns but has one interception, showing both his skill and areas for improvement.
Chiles has earned 66.5 fantasy points, ranking him first on his team and 43rd in the league. His combination of passing yards and touchdowns makes him a crucial player for the Spartans as they progress through the season.
Michigan State Spartans vs. USC Trojans Football Betting Trends
- Michigan State is 4-0 on the Over/Under in their last 4 games as an underdog.
- Additionally, Michigan State is 3-0 on the Over/Under in their last 3 games after a win.
- USC is 23-7 straight up as a favorite in their last 30 games.
- USC is 7-1 against the spread in their last 8 home games.
- Also, the Over/Under for USC in home games is 21-7 in their last 28 games.
- USC is 17-8 straight up in their last 25 games after a win.
Spartans vs Trojans Prediction: Over 55.5
Michigan State has been an over machine in the underdog role, cashing in their last four games when getting points. They’ve also hit the over in three straight following a win, which signals a pattern of higher-scoring contests when momentum is on their side.
On the other hand, USC has been just as reliable for overs at home, going 21-7 in their last 28 in Los Angeles. Their offense has been electric, ranking second in the nation with 165 total points through three games.
With USC averaging 55 points per game and Michigan State allowing 70 through three contests, this matchup has shootout written all over it.
Although the Spartans are unbeaten at 3-0, this is their first road test and first conference game of the season, and injuries could play a role in their ability to slow USC down.
Still, Michigan State’s offense is capable of keeping things interesting against a Trojan defense that hasn’t been flawless.
All factors point toward another high-scoring affair, with both teams trading punches throughout. The over 55.5 is the sharper play, as the Spartans should contribute enough to push USC’s explosive offense past the number.
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NCAAF Betting Tweet Of The Day
USC Safety Bishop Fitzgerald in Week 3:
⚔️ 50 Coverage Snaps
⚔️ 1 Catch Allowed
⚔️ 2 Interceptions
⚔️ 90.1 Coverage Grade@uscfb pic.twitter.com/71JQj2UOdc— PFF College (@PFF_College) September 15, 2025
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