Free NCAAF Pick: 49ers vs. Bulls Odds
Looking for Charlotte 49ers vs. South Florida Bulls Free NCAA Week 6 picks & NCAA odds? NCAAF betting sees the 49ers taking on the Bulls on 10/3 at Raymond James Stadium, in South Florida. Cappers Picks provides complimentary expert handicapping picks on all NCAA football matchups all season long so stay tuned for more FREE daily NCAAF predictions like this 49ers Bulls free pick.
2025 NCAAF Handicapping – Charlotte 49ers vs South Florida Bulls
(1-3) Charlotte 49ers vs. South Florida Bulls (3-1)
Date: Oct 03, 2025
Time: 7:00 PM ET
Venue: Raymond James Stadium in South Florida, FL
NCAAF Moneyline Odds: 49ers +1576 | Bulls -4803 (Bet Now!)
Today’s NCAAF Spread Betting Odds: 49ers +27.5 | Bulls -27.5
NCAAF Football Gambling Total: O/U: 54.5
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49ers vs. Bulls Gameday
Charlotte heads to Tampa with a 1-3 record and plenty of questions. They’ve played every game at home so far and still couldn’t find momentum, so now their first road trip of the season doubles as a gut check.
Sitting at 0-1 in conference play, the 49ers need something to keep them relevant in the AAC.
Meanwhile, South Florida has put itself in a stronger spot. The Bulls are 3-1, with a perfect 2-0 mark at Raymond James Stadium. Their latest outing was a 63-14 blowout of South Carolina State, the kind of performance that builds confidence heading into conference battles.
History hasn’t been kind to Charlotte, either. South Florida crushed them 59-24 last season, adding to a recent run of lopsided meetings.
So while both sides are looking to climb in the standings, one clearly has the upper hand.
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It’s Week 6, Charlotte 49ers vs. South Florida Bulls — a Friday night showcase in Tampa.
Charlotte 49ers vs. South Florida Bulls Odds & Last 5
The books aren’t hiding their opinion here. South Florida is a massive favorite at -4509, while Charlotte sits way out at +1685. That’s the kind of gap where you’d need a shocker to cash a 49ers ticket.
Looking at their last games tells the story. Charlotte dropped one to Rice, 28-17, despite winning the yardage battle.
South Florida? They looked like a different weight class, steamrolling South Carolina State by nearly 50.
Head-to-head meetings keep reinforcing the point. The Bulls have taken the last two matchups, 59-24 and 48-14.
Charlotte’s task this week is not just tough — it’s borderline uphill sprinting.
Bulls Stats
South Florida’s offense has been busy. They’ve scored 127 points (52nd nationally) behind a passing attack worth 1,062 yards. The run game sits at 537 yards, which leaves room for improvement but hasn’t held them back.
Defensively, they’ve forced turnovers at a steady clip — three fumble recoveries and four interceptions. The unit has given up 86 points, ranking 54th, showing they’re solid but not unbeatable.
Their resume includes a little bit of everything. A tight 18-16 win over Florida showed they can grind out a close one, but a 49-12 loss to Miami reminded them of the gap with top-tier talent.
The bounce-back against South Carolina State proved this team can respond.
Quarterback Byrum Brown has been the engine, throwing for 983 yards and six touchdowns in four games. Sam Franklin leads on the ground with 110 rushing yards, and Chas Nimrod has emerged as the go-to target with 367 receiving yards and two scores.
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49ers Stats
Charlotte has been hit-and-miss. They’ve scored 73 points (84th nationally) but managed 1,033 passing yards (68th). It’s a unit that can move the ball, just not consistently finish drives.
On defense, there’s no hiding the struggles. They’ve surrendered 117 points (83rd) but have at least created pressure with six sacks, ranking 15th in the nation.
That’s been their best weapon to keep games respectable.
Recent results show both sides of the coin. A 42-35 win over Monmouth was a much-needed lift, but losses to Rice, North Carolina, and Appalachian State quickly dragged them back. And now, injuries are stacking up.
Conner Harrell and Jayden McGowan being sidelined stretches their depth thin.
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49ers vs. Bulls QB Matchup
South Florida knows its guy. Byrum Brown leads the way with nearly 1,000 passing yards already, plus six TDs against two picks. He’s steering a steady ship, and Locklan Hewlett’s limited reps (45 yards, one TD) don’t change that.
Charlotte leans on Conner Harrell, who has thrown for 737 yards with four touchdowns and two interceptions in four games. He’s been serviceable, but the inconsistency has been clear.
Backup Grayson Loftis has added 296 yards and one touchdown in three appearances, though turnovers have been an issue there too.
Bottom line: the Bulls have stability under center, while Charlotte is trying to keep pace with fewer weapons and less protection.
Charlotte 49ers vs. South Florida Bulls Football Betting Trends
- Charlotte has a strong record against the spread in away games, going 12-4 over their last 16 games.
- Also, Charlotte tends to hit the over in away games, with an 8-1 record in their last 9 games.
- Charlotte is 6-3 on the over following a loss in their last 9 games.
- South Florida has been perfect against the spread at home, going 4-0 in their last 4 games.
- Additionally, South Florida has hit the over in all 6 of their recent games as favorites.
- South Florida has a 6-2 record against the spread as favorites in their last 8 games.
49ers vs Bulls Prediction: Over 54.5
Charlotte has been an over machine on the road, cashing 8 of their last 9 away games to the over. That trend shows they either score enough or allow enough points to push games past the total.
Playing away from home seems to open things up offensively and defensively for the 49ers.
Meanwhile, South Florida has hit the over in all six of their recent games as favorites, showing their offense tends to explode when expected to win.
At home, the Bulls have no issue finding ways to put points on the board, and Charlotte’s defense doesn’t exactly profile as one that can keep them in check.
With both teams leaning heavily toward high-scoring results, it’s tough to see this matchup staying under.
Given the total is set at 54.5, oddsmakers are daring bettors to trust the defenses. However, my system strongly suggests otherwise, making the over the logical pick in this spot.
Today’s NCAAF Free Pick
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NCAAF Betting Tweet Of The Day
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