Free NCAA Pick: BYU vs. Colorado Odds
Looking for BYU Cougars vs. Colorado Buffaloes free NCAA Week 5 picks & NCAA odds? NCAA betting sees the Cougars taking on the Buffaloes on Saturday, September 27th at the Folsom Field (CO). Cappers Picks provides complimentary NCAA handicapping picks all season long including all NCAA Week 5 games so stay tuned for more FREE NCAA predictions like this BYU Colorado matchup.
2025 NCAAF Handicapping Analysis: Week 5
(3-0) BYU Cougars vs. Colorado Buffaloes (2-2)/strong>
Date: Saturday, September 27th
Time: 10:15PM ET
Venue: Folsom Field in Boulder, CO
Week 5 ATS Betting Lines: (BET NOW!) BYU -6.5 | Colorado +6.5
Week 5 CFB Moneyline Odds: BYU -250 | Colorado +200
College Football Betting Total: O/U 49.5
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The Cougars head to Colorado flying high after starting their season off in spectacular fashion, as they’ve yet to lose. On the flip side, the Buffaloes are sitting 2-2 and have lost both games they were underdogs in.
Interestingly, the line is sitting at -6.5 for the Cougars, and they’ve impressively covered every single game this season, even winning 69-0 with a -43.5 line. While Colorado has only covered once this year, going 1-3 ATS so far.
The first and only time these teams have played was back in 2024, and BYU won on the road by a 36-14 score, as 3-point underdogs.
BYU
The Cougars are on a roll this year, winning 3 games in a row by a combined 130-16 score. Last week’s contest was against the East Carolina Pirates, and they were favored by -6.5 but won by a 34-13 score.
After their amazing start, you’d think the line would be much larger than it currently is, but this does open up BYU bettors to a potential profitable week.
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BYU Cougars Stats
Amazingly, BYU is ranked 7th in the league for rushing yards per game, at a whopping 265.7 YPG. They gain this yardage by an average of 41 rush attempts per game and 6.5 yards per carry.
While this squad is amazing on the ground, they’ve struggled in the air, as they rank 102nd in pass yards per game, with a measly 186.3 yards.
With all that being said, they haven’t been forced to using their passing game, as they’ve dominated games with the run. For all we know, they’re just as dominate in the air, and may see that unfold this week.
Another important note, BYU’s defense is also ranked 2nd in yards against, 1st in yards per play, and 2nd in rush yards against and 1st in yards per rush.
Colorado Buffaloes
After going 1-2 in their first 3 games, the Buffaloes turned things around last week with a 37-20 win over Wyoming. Spectacularly, they also managed to cover the 12.5 point spread in this matchup as well.
If Colorado wants to pull off the upset in this game, they’ll have to avoid the turnovers, as both active QB’s have combined for 4 interceptions so far this year and will be going up against consistent pressure in this game.
Colorado Buffaloes Stats
To start, the Buffaloes offense has been lackluster, as they’re ranked 83rd for yards, with 375 per game. Additionally, they’re ranked just 90th for rush yards and 68th for pass yards.
Their defense isn’t much better, ranked 112th for yards against allowing a shocking 409.2 per matchup. Colorado is also permitting a monstrous 194.5 rush yards per game, ranking 123rd in the league.
With all the negative stats mentioned, they do shine against the pass, as they’re ranked 18th for completions and 17th for completion percentage against.
BYU Cougars vs. Colorado Buffaloes NCAA Football Betting Trends
- Impressively, the BYU Cougars are 8-2 SU in their last ten games overall.
- While the Colorado Buffaloes are just 6-4 SU in their last ten games overall.
- The BYU Cougars are 5-4-1 ATS in their last ten games.
- On the flip, the Colorado Buffaloes have also gone 5-4-1 ATS across their last ten games.
- In BYU’s last 10 games, their over/under record is 6-4.
- Oppositely, the Colorado Buffaloes’ have an over/under record of 4-5-1 in their last 10 games.
- The head-to-head record between these teams is 1-0 in favor of BYU.
4* Free 2025 Week 5 NCAA Betting Prediction: BYU -6.5
In this matchup, BYU’s defense and their run game should be too much for the Buffaloes to handle.
Mainly because the Cougars are basically the best in the league against the run and can continuously put pressure on the QB. To add to this, they also have a dominate defense which could lead to mistakes for Colorado’s backfield.
Due to the aforementioned points, I believe the line should be further in BYU’s favor, which gives us an easy pick for them to cover on Saturday night.
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BYU Cougars vs. Colorado Buffaloes NCAA Betting Tweet Of The Day
Go mode. #BeatBYU pic.twitter.com/3gigGmczrq
— Colorado Buffaloes Football (@CUBuffsFootball) September 27, 2025
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