Free NCAAF Pick: Wildcats vs. Cyclones Odds
Looking for Arizona Wildcats vs. Iowa State Cyclones Free NCAA Week 5 picks & NCAA odds? NCAAF betting sees the Wildcats taking on the Cyclones on 9/27 at Jack Trice Stadium, in Iowa State. Cappers Picks provides complimentary expert handicapping picks on all NCAA football matchups all season long so stay tuned for more FREE daily NCAAF predictions like this Wildcats Cyclones free pick.
2025 NCAAF Handicapping – Arizona Wildcats vs Iowa State Cyclones
(3-0) Arizona Wildcats vs. Iowa State Cyclones (4-0)
Date: Sep 27, 2025
Time: 7:00 PM ET
Venue: Jack Trice Stadium in Iowa State, IA
NCAAF Moneyline Odds: Wildcats +178 | Cyclones -222 (Bet Now!)
Today’s NCAAF Spread Betting Odds: Wildcats +5.5 | Cyclones -5.5
NCAAF Football Gambling Total: O/U: 49.5
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Wildcats vs. Cyclones Gameday
To begin, the Arizona Wildcats are heading to Iowa to take on the Iowa State Cyclones. This week 5 game takes place at Jack Trice Stadium. Fans can watch the action on ESPN at 7:00 PM.
Arizona Wildcats have had a strong start this season with a 3-0 record. They have played all their games at home so far. Now, they face their first road test against a tough opponent.
Meanwhile, Iowa State Cyclones come into this game with a 4-0 record. They have already secured three victories at home this season. They are currently ranked 14th in the AP Poll and 13th in the Coaches Poll.
Both teams belong to the Big 12 Conference, making this matchup even more exciting. Arizona is on a three-game win streak, while Iowa State has won four straight. Expect an intense game under the lights in Ames.
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It’s Week 5, Arizona Wildcats vs. Iowa State Cyclones, hopefully we get a great matchup.
Arizona Wildcats vs. Iowa State Cyclones Odds & Last 5
Next, let’s look at the game odds. The Arizona Wildcats have a moneyline of +185, while Iowa State Cyclones sit at -225. The spread favors Iowa State by 5.5 points, and the over/under is set at 49.5.
In previous games, Arizona has shown strong performances at home. They recently defeated Kansas State 23-17, securing 21 first downs. Their passing and rushing have been impressive, as seen in earlier games against Weber State and Hawaii.
Meanwhile, Iowa State has been solid both at home and on the road. They edged past Arkansas State 24-16 in their most recent road game.
This followed a narrow 16-13 win over Iowa in a close game at home.
Cyclones Stats
Meanwhile, the Iowa State Cyclones are on a roll this season. They have won all four of their games, showing strong performances on both offense and defense. Their latest victory was a 24-16 win over Arkansas State, where they gained 265 passing yards and 189 rushing yards.
On offense, the Cyclones rank 40th in points scored with 119. They have accumulated 888 passing yards, ranking 61st, and 648 rushing yards, ranking 54th. Rocco Becht leads the team with 860 passing yards and seven touchdowns.
Defensively, Iowa State has been solid, allowing just 57 points, which ranks them 33rd. They have also recorded eight sacks and four interceptions, ranking 10th and 5th, respectively. The defense has been crucial in their recent wins, keeping opponents at bay.
In terms of injuries, the Cyclones have several players listed as day to day, including key contributors like Kyle Konrardy and Gabe Burkle. Despite these setbacks, the team has maintained momentum.
They will look to continue their winning streak in upcoming games.
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Wildcats Stats
To begin with, the Arizona Wildcats have been on a roll this season. They have won their first three games, showing strong performances against Hawaii, Weber State, and Kansas State. Their offense has scored a total of 111 points, placing them at 45th in the nation.
Next, their defense has been rock solid, allowing only 26 points over three games. This ranks them 6th in points against, and they have been effective in creating turnovers. They rank 6th in interceptions with five and 3rd in fumbles recovered with three.
Quarterback Noah Fifita has been a standout player for Arizona. He has thrown for 712 yards and six touchdowns without any interceptions. This performance has helped the Wildcats maintain their winning momentum.
In addition, running back Ismail Mahdi has contributed significantly to the ground game. He has rushed for 263 yards and scored one touchdown.
However, the team faces some injury concerns with key players like Riley Wilson and Kedrick Reescano listed as day to day.
We want to hear from you below! Comments are welcome! Give us your picks for this Arizona Wildcats vs. Iowa State Cyclones NCAAF matchup.
Wildcats vs. Cyclones QB Matchup
Rocco Becht leads the Iowa State Cyclones with impressive stats. In four games, he has thrown for 860 yards, ranking first on his team. Additionally, he has seven passing touchdowns and just one interception.
Alex Manske, another Cyclones quarterback, has played in one game. He has 28 passing yards, which places him second on the team. However, he has yet to throw a touchdown or interception.
Noah Fifita is the top quarterback for the Arizona Wildcats. Over three games, he has accumulated 712 passing yards, leading his team. He also has six touchdowns and no interceptions, highlighting his strong performance.
Mason Bray, another quarterback for the Wildcats, has played in one game. He has 22 passing yards, ranking second on the team. Like Manske, Bray has not thrown a touchdown or interception yet.
Arizona Wildcats vs. Iowa State Cyclones Football Betting Trends
- Arizona is 9-3 straight up in their last 12 games after a win.
- Arizona is 4-1 on the over/under in their last 5 games as an underdog.
- Also, Arizona is 17-12 against the spread as an underdog in their last 29 games.
- Iowa State is 12-2 straight up in their last 14 games after a win.
- Additionally, Iowa State is 9-1 straight up in their last 10 home games.
- Iowa State is 4-1 against the spread in their last 5 home games.
Wildcats vs Cyclones Prediction: Iowa State -5.5
Arizona has shown value as an underdog, covering 17 of their last 29 games in that role. However, this will be their first true road test of the season, and Jack Trice Stadium is no easy place to walk into and succeed.
Iowa State enters this matchup riding a perfect 4-0 start while climbing high in both the AP and Coaches polls. Even more, the Cyclones have been nearly automatic at home, going 9-1 straight up in their last 10 games in Ames.
Arizona’s defense may rank 6th in points allowed, but Iowa State’s balanced attack through the air and on the ground gives them the blueprint to find cracks.
Furthermore, the Cyclones’ defense should keep them in control, forcing Arizona to play from behind in a hostile setting. Their overall consistency in front of their home crowd makes them the sharper side.
Considering Iowa State’s recent form, home dominance, and Arizona’s lack of road experience, laying -5.5 is the smart play.
I’m predicting to see the Cyclones extend their winning streak and cover comfortably on Saturday.
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NCAAF Betting Tweet Of The Day
11 AM at Cincinnati. pic.twitter.com/CpzbjfyqrY
— Iowa State Football (@CycloneFB) September 22, 2025
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