Free AI MLB Prediction: Cardinals at Pirates Odds
If you’re searching for St. Louis Cardinals at Pittsburgh Pirates AI computer MLB baseball free predictions look no further! This game takes place on Tuesday, September 22nd at PNC Park, in Pittsburgh. At this time, our AI MLB computer prediction model has the gambling analysis, baseball betting trends, and outcome locked in. In fact, when you’re ready, just scroll down to get the free AI MLB pick.
MLB Handicapping – St. Louis Cardinals at Pittsburgh Pirates AI MLB Baseball Prediction
- (76-80) St. Louis Cardinals at Pittsburgh Pirates (79-77)
- MLB Starting Pitchers: Andre Pallante vs. Jared Jones
- Date: Tuesday, September 22nd
- Time: 6:40 PM ET
- Venue: PNC Park Pittsburgh, PA
- MLB Moneyline Odds: Cardinals +127 | Pirates -150 (Bet Now!)
- Runline MLB Odds: Cardinals +1.5 | Pirates -1.5
- MLB Betting Total: O/U: 7
As can be seen, artificial intelligence (AI) is used by CappersPicks.com to sort through vast quantities of data and identify the best outcomes for free computer picks on MLB baseball betting each day. For one thing, we save you tons of time and energy researching your selections by giving you our daily AI best bets. In fact, scroll down for today’s St. Louis Cardinals at Pittsburgh Pirates AI MLB prediction.
Cardinals vs. Pirates Starting Lineups
The projected starting lineups for the St. Louis Cardinals at Pittsburgh Pirates game today offers plenty of insight into how each club plans to attack this matchup. Additionally, keep an eye on roster shifts, platoon advantages, and lineup depth before placing your MLB bets.
| Player Name | Batting Order | Position |
|---|---|---|
| JJ Wetherholt | 1 | 2B |
| Iván Herrera | 2 | DH |
| Alec Burleson | 3 | 1B |
| Jordan Walker | 4 | RF |
| Bryan Torres | 5 | LF |
| Nathan Church | 6 | CF |
| Nolan Gorman | 7 | 3B |
| Pedro Pagés | 8 | C |
| Masyn Winn | 9 | SS |
| Starting Pitcher | – | SP |
| Player Name | Batting Order | Position |
|---|---|---|
| Spencer Horwitz | 1 | 1B |
| Brandon Lowe | 2 | 2B |
| Bryan Reynolds | 3 | LF |
| Nick Gonzales | 4 | DH |
| Oneil Cruz | 5 | CF |
| Konnor Griffin | 6 | SS |
| Rafael Flores Jr. | 7 | C |
| Jake Mangum | 8 | RF |
| Jared Triolo | 9 | 3B |
| Starting Pitcher | – | SP |
Cardinals vs. Pirates AI Last Five Head To Head Trends
- In the last 3 games of the 2026 regular season, the Pirates lead the series 2-1 against the Cardinals.
- Over the last 5 games in 2026, the Pirates have a 4-1 record against the Cardinals.
- The Cardinals have covered the run line in 3 of the last 5 games against the Pirates in 2026.
- In the last 10 games of 2026, the total has gone over in 6 of those games between the Pirates and Cardinals.
St. Louis Cardinals vs. Pittsburgh Pirates MLB Betting Trends
Before locking in your pick for the St. Louis Cardinals vs. Pittsburgh Pirates matchup, take a look at some key betting trends. Indeed, both teams have shown strong patterns in specific spots — and these stats could help uncover where the value lies on today’s MLB betting card.
- The Cardinals are 4-6 straight up in their last 10 games.
- Also, the Cardinals have a runline record of 66-40 as an underdog, which is 62.3%.
- The Cardinals have gone over the total in 7 of their last 10 games.
- The Pirates are 4-1 straight up in their last 5 games.
- Additionally, the Pirates have covered the runline in their last 5 games, going 5-0.
- The Pirates have an over/under record of 47-31 in home games, which is 60.3% over.
Cardinals Injury Report
| Player | Status | Injury |
|---|---|---|
| Everson Pereira | Out | Hand |
| Blaze Jordan | Out | Ankle |
| Joshua Báez | Out | Oblique |
| Hunter Dobbins | Out | Forearm |
| Max Rajcic | Out | Elbow |
Pirates Injury Report
| Player | Status | Injury |
|---|---|---|
| Kirby Yates (RP) | Out | Shoulder |
| Mitch Keller (SP) | Out | Arm |
| Braxton Ashcraft (SP) | Out | Arm |
| Isaac Mattson (RP) | Out | Hip |
| Esmerlyn Valdez (RF) | Out | Hamstring |
| Endy Rodríguez (C) | Out | Hip |
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Today’s Free Cardinals at Pirates MLB Free AI Pick
NEXT MLB BASEBALL AI PICK
Not sure what amount to bet on this Cardinals at Pirates AI MLB prediction? Just like our experts we give star ratings on our plays. So far, these AI MLB computer picks are rated 4*.
- 1% of your bankroll for 4* or less.
- 2% for 5* and 6*.
- Also, 4% for 7* or higher.
Expert MLB Betting Picks
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Odds Comparison: St. Louis Cardinals at Pittsburgh Pirates
Below are the updated St. Louis vs. Pittsburgh MLB odds used by our AI prediction model.
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