Free AI NCAA Football Prediction: SMU at Louisville Odds
If you’re searching for SMU Mustangs at Louisville Cardinals AI computer NCAA football free predictions look no further! This game takes place on Saturday, September 19th at L&N Federal Credit Union Stadium, in Louisville, KY. At this time, our AI NCAA football computer prediction model has the gambling analysis, football betting trends, and outcome locked in. In fact, when you’re ready, just scroll down to get the free AI NCAA football pick.
NCAA Football Handicapping – SMU Mustangs at Louisville Cardinals AI NCAA Football Prediction
- (2-0) SMU Mustangs at Louisville Cardinals (1-1)
- Date: Saturday, September 19th
- Time: 3:30 PM ET
- Venue: L&N Federal Credit Union Stadium in Louisville, KY
- NCAAF Moneyline Odds: SMU +103 | Louisville -127 (Bet Now!)
- NCAAF ATS Odds: SMU +2 | Louisville -2
- NCAAF Betting Total: O/U: 59.5
As can be seen, artificial intelligence (AI) is used by CappersPicks.com to sort through vast quantities of data and identify the best outcomes for free computer picks on NCAA football betting each day. For one thing, we save you tons of time and energy researching your selections by giving you our daily AI best bets. In fact, scroll down for today’s SMU Mustangs at Louisville Cardinals AI NCAA football prediction.
Offensive NCAA Football Stats
| Stat | SMU | Louisville |
|---|---|---|
| PPG | 41.5 (25th) | 48.5 (15th) |
| YPG | 566 (2nd) | 566.5 (15th) |
| RUSH YPG | 124 (94th) | 225.5 (32nd) |
| PASS YPG | 442 (2nd) | 341 (15th) |
Defensive NCAA Football Stats
| Stat | SMU | Louisville |
|---|---|---|
| PPG ALLWD | 34 (22nd) | 54 (42nd) |
| TO | 1 (2nd) | 1 (2nd) |
| SACKS | 5 (8th) | 1 (12th) |
SMU vs. Louisville AI Last Five Head To Head Trends
- In the 2025 season, SMU won against Louisville with a score of 38-6.
- SMU covered the spread of +3.5 in the 2025 game.
- The total went UNDER 49.5 points in their 2025 meeting.
- In the 2024 season, SMU beat Louisville 34-27, covering a -6.5 spread.
SMU Mustangs vs. Louisville Cardinals Betting Trends
Before locking in your pick for the SMU Mustangs vs. Louisville Cardinals matchup, take a look at some key betting trends. Indeed, both teams have shown strong patterns in specific spots — and these stats could help uncover where the value lies on today’s NCAA football betting card.
- SMU has excelled in away games, winning 14 of their last 17.
- Also, the Mustangs have a strong record after a win, going 23-6 in their last 29 games.
- The Cardinals have been solid at home, winning 22 of their last 28 games.
- Louisville is on a roll as favorites, with a 23-7 record in their last 30 games.
- Additionally, the Cardinals have covered the spread in their last three games.
- SMU has covered the spread in 5 of their last 6 games as underdogs.
SMU Injury Report
| Player | Status | Injury |
|---|---|---|
| Ahmaad Moses (S) | Questionable | |
| Caden Marshall (LB) | Questionable | |
| Abel Hoopii (OL) | Out | Foot |
| Link Rhodes (RB) | Out | Knee |
| Kenneth Goodwin III (LB) | Questionable | |
| Christian Rhodes (RB) | Out | Hamstring |
| Deuce Gilbert (CB) | Questionable | |
| EJ Kelly (RB) | Questionable |
Louisville Injury Report
| Player | Status | Injury |
|---|---|---|
| Keyjuan Brown | Questionable | |
| Kris Hughes | Out | Lower Body |
| Montavin Quisenberry | Out | Lower Body |
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Today’s Free SMU at Louisville NCAA Football Free AI Pick
NCAA Football Free Score Prediction: Mustangs 31 – Cardinals 28 (Bet Now!) Our AI likes Mustangs to win by 3.
NEXT NCAA FOOTBALL AI PICK
Considering SMU’s strong start this season and their impressive passing game, they have the edge. Additionally, their recent head-to-head success against Louisville supports this pick.
Not sure what amount to bet on this SMU at Louisville AI NCAA Football prediction? Just like our experts we give star ratings on our plays. So far, these AI NCAA football computer picks are rated 4*.
- 1% of your bankroll for 4* or less.
- 2% for 5* and 6*.
- Also, 4% for 7* or higher.
Expert NCAA Football Betting Picks
Need a few more angles for this week’s college football slate? Browse today’s featured premium plays from CappersPicks handicappers, with sides, totals, moneylines, and other NCAA football bets.
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Odds Comparison: SMU Mustangs at Louisville Cardinals
Below are the updated SMU vs. Louisville NCAA football odds used by our AI prediction model.
20+ Years Handicapping NCAA football
Most important, with 20 years of handicapping data, our AI picks will deliver accurate predictions and easy-to-use tools to enhance your bets on every NCAA football game we can get to. Hopefully you like our SMU Mustangs at Louisville Cardinals AI NCAA football prediction today! After all, it’s a free NCAA football pick, right? Enjoy!
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