Free AI MLB Prediction: Astros at Cubs Odds
If you’re searching for Houston Astros at Chicago Cubs AI computer MLB baseball free predictions look no further! This game takes place on Friday, May 22nd at Wrigley Field, in Chicago. At this time, our AI MLB computer prediction model has the gambling analysis, baseball betting trends, and outcome locked in. In fact, when you’re ready, just scroll down to get the free AI MLB pick.
MLB Handicapping – Houston Astros at Chicago Cubs AI MLB Baseball Prediction
- (20-31) Houston Astros at Chicago Cubs (29-21)
- MLB Starting Pitchers: Spencer Arrighetti vs. Jameson Taillon
- Date: Friday, May 22nd
- Time: 2:20 PM ET
- Venue: Wrigley Field Chicago, IL
- MLB Moneyline Odds: Astros +123 | Cubs -148 (Bet Now!)
- Runline MLB Odds: Astros +1.5 | Cubs -1.5
- MLB Betting Total: O/U: 7
As can be seen, artificial intelligence (AI) is used by CappersPicks.com to sort through vast quantities of data and identify the best outcomes for free computer picks on MLB baseball betting each day. For one thing, we save you tons of time and energy researching your selections by giving you our daily AI best bets. In fact, scroll down for today’s Houston Astros at Chicago Cubs AI MLB prediction.
Astros vs. Cubs Starting Lineups
The projected starting lineups for the Houston Astros at Chicago Cubs game today offers plenty of insight into how each club plans to attack this matchup. Additionally, keep an eye on roster shifts, platoon advantages, and lineup depth before placing your MLB bets.
| Player Name | Batting Order | Position |
|---|---|---|
| Jeremy Peña | 1 | SS |
| Yordan Alvarez | 2 | DH |
| Isaac Paredes | 3 | 3B |
| Christian Walker | 4 | 1B |
| Jake Meyers | 5 | CF |
| Zach Cole | 6 | LF |
| Brice Matthews | 7 | 2B |
| Cam Smith | 8 | RF |
| Christian Vázquez | 9 | C |
| Starting Pitcher | – | SP |
| Player Name | Batting Order | Position |
|---|---|---|
| Nico Hoerner | 1 | 2B |
| Michael Busch | 2 | 1B |
| Alex Bregman | 3 | 3B |
| Ian Happ | 4 | LF |
| Seiya Suzuki | 5 | RF |
| Moisés Ballesteros | 6 | DH |
| Carson Kelly | 7 | C |
| Pete Crow-Armstrong | 8 | CF |
| Dansby Swanson | 9 | SS |
| Starting Pitcher | – | SP |
Astros vs. Cubs AI Last Five Head To Head Trends
- In 2025, the Astros won 2 out of 3 games against the Cubs.
- The Cubs covered the run line in 2 out of 3 games in 2025.
- In 2025, 2 out of 3 games went OVER the total.
- In 2024, the Cubs won all 3 games against the Astros.
Houston Astros vs. Chicago Cubs MLB Betting Trends
Before locking in your pick for the Houston Astros vs. Chicago Cubs matchup, take a look at some key betting trends. Indeed, both teams have shown strong patterns in specific spots — and these stats could help uncover where the value lies on today’s MLB betting card.
- The Astros are 8-17 straight up in away games this season.
- The Cubs have a strong 18-8 straight up record in home games.
- Also, the Cubs are 9-3 straight up in 1-run games, showing they can win close ones.
- The Astros are 4-2 straight up in 1-run games, showing a similar trend in tight contests.
- Additionally, the Astros have gone 15-8 on over/under totals of 9 or more.
- The Cubs have gone 11-3 on over/under totals of 9 or more, indicating high-scoring games.
Astros Injury Report
| Player | Status | Injury |
|---|---|---|
| Jose Altuve (2B) | Out | Oblique |
| Carlos Correa (SS) | Out | Ankle |
| Lance McCullers Jr. (SP) | Out | Shoulder |
| Josh Hader (RP) | Out | Bicep |
| Taylor Trammell (CF) | Out | Groin |
| Cristian Javier (SP) | Out | Shoulder |
| Ronel Blanco (SP) | Out | Elbow |
| Bennett Sousa (RP) | Out | Elbow |
| Hayden Wesneski (SP) | Out | Elbow |
| Hunter Brown (SP) | Out | Shoulder |
| Yainer Diaz (C) | Out | Oblique |
| Joey Loperfido (LF) | Out | Quad |
Cubs Injury Report
| Player | Status | Injury |
|---|---|---|
| Shelby Miller (RP) | Out | Elbow |
| Tyler Austin (1B) | Out | Knee |
| Hunter Harvey (RP) | Out | Tricep |
| Matthew Boyd (SP) | Out | Knee |
| Justin Steele (SP) | Out | Elbow |
| Edward Cabrera (SP) | Day-to-Day | Finger |
| Riley Martin (RP) | Out | Elbow |
| Cade Horton (SP) | Out | Forearm |
| Porter Hodge (RP) | Out | Elbow |
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Today’s Free Astros at Cubs MLB Free AI Pick
MLB Free Score Prediction: Astros 3 – Cubs 4 (Bet Now!) Our AI likes Cubs to win by 1.
NEXT MLB BASEBALL AI PICK
Not sure what amount to bet on this Astros at Cubs AI MLB prediction? Just like our experts we give star ratings on our plays. So far, these AI MLB computer picks are rated 4*.
- 1% of your bankroll for 4* or less.
- 2% for 5* and 6*.
- Also, 4% for 7* or higher.
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Odds Comparison: Houston Astros at Chicago Cubs
Below are the updated Houston vs. Chicago MLB odds used by our AI prediction model.
20+ Years Handicapping MLB
Most important, with 20 years of handicapping data, our AI picks will deliver accurate predictions and easy-to-use tools to enhance your bets on every MLB baseball game we can get to. Hopefully you like our Houston Astros at Chicago Cubs AI MLB prediction today! After all, it’s a free MLB baseball pick, right? Enjoy!
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