Detroit vs San Francisco Betting
Handshake Bowl II – Detroit Lions in Early Litmus Test versus 49ers in Week 2
Week 2 of the NFL schedule features a number of marquee matchups with one taking place by the Bay. The San Francisco 49ers, impressive winners in Week 1 on the road over the Green Bay Packers play their home opener on Sunday versus a Detroit Lions team that may have been lucky to escape the NFL’s opening week with a win over the St. Louis Rams.
