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Week 13 49ers vs. Bills NFL Predictions

NFL Week 13 Betting – San Francisco 49ers at Buffalo Bills

The San Francisco 49ers (3-8 SU, 4-7 ATS) like to think they are making some competitive progress under interim coach Mike Singletary. On Sunday they will take their shot at the Buffalo Bills (6-5 SU, 5-6 ATS), off an unexpected offensive explosion, in NFL pro football sports betting action that is slated to begin at 1 PM ET at Ralph Wilson Stadium (artificial turf) in Orchard Park, NY.