– Last Updated on November 21, 2022 2:51 pm
NFL Week 6 Odds + Predictions
Looking for NFL Week 6 Odds and free NFL picks? Week 6 of the NFL Regular Season kicks off on Thursday night – another quality slate of games is on tap for all of us to digest. If the first five weeks taught us anything it is that there is no sure-thing in the NFL – parity is a real thing! That said there are a number of games that look, on paper like slam dunks– but there were last week as well!
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Let’s take a look at the teams that ARE in action this week, the early lines for each of those games and what should play out on what promises to be another incredible week of NFL football.
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NFL Week 6 Odds for Week 6 NFL Action
With that in mind, let’s take a look at every game this weekend, the odds that accompany those games and what I think should play out.
Broncos at Chargers (Opening line: Broncos, -2 points)
The Broncos are favorites on the road against a Chargers team that seems to be inventing new ways to lose each and every week. Philip Rivers and crew haven’t yet faced anything like the defense they are about to see with Denver.
Even if Paxton Lynch is forced to start (my guess is that Trevor Siemian will be under center) the Broncos should control this game. Denver is still a top tier team while San Diego is in the bottom tier of NFL clubs.
The Chargers are 1-4 ATS in their last five as home underdog and they have lost 10 straight in their division. It all adds up to an easy Denver win.
Bengals at Patriots (Opening line: Patriots, –6.5 points)
The Pats will be at least a 7 point favorite at home Sunday as Tom Brady looks to build on an impressive effort in his first game back from suspension.
Brady has been money at home in his career – 25-0 SU in non-divisional games at Foxboro and 20-0-8 ATS in his last 28 there.
Cincinnati hasn’t won at New England in 30 years – don’t expect it to happen Sunday as Brady and the boys keep the foot on the pedal and beat up on an underwhelming Bengals defense.
Ravens at Giants (Opening line: Giants, -3 points)
Two teams that have been on a bit of a slide meet in Week 6 when the Ravens travel to New York to take on the Giants. The Giants are favored by three despite Baltimore entering the week with the top rated defense in the game.
Eli looks out of sorts right now – he is awful against top flight defenses. I expect his struggles to continue and for Baltimore to pull the mild upset here.
Panthers at Saints (Opening line: Panthers, -2 points)
The Panthers will be dependent on Cam Newton – period. They are in a freefall this season and it is not just the offense that can take the blame. Carolina’s defense has been awful – even Jacquizz Rodgers had success against them on Monday night.
The Saints WILL score points on this defense and I can’t see the Panthers scoring enough to post the win.
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Take a bad Saints team to sneak a win against a bad Panthers squad.
Steelers at Dolphins (Opening line: Steelers, -7 points)
The Dolphins are horrible – maybe one of the worst teams in the game right now. On Sunday they face Big Ben and a Steelers offense that is on fire.
The Steelers have outscored their opposition 74-27 the last two weeks (against the Jets and the Chiefs) and Big Ben has thrown for 680 yards and nine TDs in those games – the Fins just gave up 30 points to the Titans for heaven’s sake.
This is the blowout of the weekend with Pittsburgh easily winning.
Jaguars at Bears (Opening line: Bears, -2 points)
Ugh! I guess this game comes down to the availability of Jay Cutler. That said Brian Hoyer may be the better QB right now. The Bears are 0-3 ATS as home favorites in their last three opportunities and are just 1-4 ATS overall in 2016.
Take the Jags, off their bye to do just enough to add to Chicago’s woes.
49ers at Bills (Opening line: Bills, -7 points)
Another game that we have no idea who a starting QB will be – early word is that Colin Kaepernick may make his debut for San Francisco. If that’s not bad enough the 49ers have traditionally struggled badly in games on the East Coast – 1-5 in their last six.
They also have a hard time with the AFC – 2-6 ATS in their last eight. Shady McCoy and an emerging Bills offense should feast on Sunday as they blow out the 49ers by at least 10 points.
Rams at Lions (Opening line: Lions 2.5 points).
The Lions played pretty well last week in a win over the Eagles – optimism for this team indeed. The Rams have been falling back to earth on the other hand. Now Los Angeles flies across country with a defense that has been absolutely been decimated by injury.
The Rams have been one of the worst road teams in the game – 10-16-1 ATS in the last 27 – I expect the woes to continue Sunday and for the Lions to get their second win in a row.
Browns at Titans (Opening line: Titans, -6 points)
I think I just barfed in my mouth! How are the Titans a 6 point favorite? Oh ya – they are at home against the Browns! Cleveland could be starting their fourth string QB on Sunday – get the Titans before the line swells to 10 points!
I like Tennessee by at least 7!
Eagles at Redskins (Opening line: Pick’em)
The Eagles will likely be favored by game time – my guess is 2 points. The Redskins have won three straight against their divisional foe but I actually like the Eagles to snap that streak Sunday.
Truth be told Philadelphia is a very well-balanced team – they are stout on defense and their offense has been terrific outstanding.
If Ryan Matthews could hold onto the ball! Philly is 4-1 ATS on the year and I think they go 5-1 against an average looking Washington team Sunday.
Chiefs at Raiders (Opening line: Raiders, -2 points)
This game represents Andy Reid’s return from a bye – he has been masterful in his career in this situation – 15-2 SU after the bye – wow. He is also 5-1 SU in his six games as Chiefs coach against the Raiders.
Although this is a different Raiders team, the numbers don’t lie – Reid with an extra week to prepare should be able to guide a healthy Chiefs team to a win.
Falcons at Seahawks (Opening line: Seahawks, -6 points)
Who would have thought that this game would be an absolute marquee matchup? The Falcons enter off consecutive wins against the teams that contested the Super Bowl last year – Carolina and Denver! Impressive.
Atlanta’s offense has beaten down the Panthers and the Broncos defense – incredible and is second in the NFL. The Hawks are favored because of their insane home field advantage and the fact that they are coming off their bye.
This is a tough one for me but I’m taking Seattle to bring the Falcons back down to earth by a touchdown.
Cowboys at Packers (Opening line: Packers, -5.5 points)
Another juicy matchup! The Cowboys are getting no respect! The Cowboys are 0-5 SU in the last five matchups with the Packers but the Boys are 4-1 SATS so far this year.
This matchup comes down to Zeke Elliot versus the league’s best run defense – I think Zeke wins! The league’s leading rusher should have a solid game behind the best O-line in the game which keeps Aaron Rodgers off the field and makes this game close.
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I’m not saying that Dallas wins but I see this as a very close game. I’m taking the Pack to win but by just 3 points.
Colts at Texans (Opening line: Texans, 3.5 points)
Do you trust Brock Osweiler? I don’t. Add in the fact that Indianapolis is 6-2 against Houston in the last eight matchups and 4-1-1 ATS in the last six and this looks like an Indianapolis win.
Look, the Colts aren’t great but they show up in Divisional games and they are facing what has been an awful Houston team. Take the road upset here.
Jets at Cardinals (Opening line: Cardinals, -6.5 points).
It looks as though Carson Palmer will suit up Monday night which is crucial for Arizona. Simply put they the Cardinals are the much better team that get a shot at a pretty bad all-around Jets team on home turf.
This looks like a 9-10 point win for Arizona here.
Bye Weeks: Vikings, Buccaneers
NFL Week 6 Handicapping
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