San Francisco vs. Indianapolis Pointspread

[Shame About Ray]

Oddsmakers currently have the Colts listed as 12½-point favorites versus the 49ers, while the game's total is sitting at 45. We give you our Week 8 NFL Predictions for this San Francisco 49ers vs. Indianapolis Colts matchup...

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Week 8 Spreads: San Francisco vs. Indianapolis

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[TheWiesguy]

Like SF to cover in this one. Alex Smith vs Peyton Manning seems like a huge mismatch. It is but the rest of the teams matches up pretty well. They will never threaten the upset but can keep it close enough to cover.

Indy 30
SF 26